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Melanoma Sequential Immune Checkpoint Blockade Treatment Sequencing Study

ABSTRACT:

Blockade of T cell coinhibitory molecules such as CTLA-4 and PD-1, can activate T cell antitumor response. Although these immune checkpoint blockades (CTLA-4 blockade and PD-1 blockade) have shown durable response, response rate is modest. Therefore, there is a need to find stable biomarkers predictive of response to immune checkpoint blockades and to understand underlying resistance mechanisms. We collected longitudinal tumor biopsies from a cohort of metastatic melanoma patients treated with sequential immune checkpoint blockades and performed whole exome sequencing of this cohort. The comprehensive genomic characterization of tumors enabled identification of higher copy number loss burden as a resistance mechanism and clonal T cell repertoire as a predictive biomarker.

PROVIDER: phs001425 | dbGaP |

SECONDARY ACCESSION(S): PRJNA397812PRJNA397813

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs001425.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001425.Melanoma_ImmuneCheckpoint.v1.p1.MULTI.pdf	Pdf
	manifest_phs001425.Melanoma_ImmuneCheckpoint.v1.p1.c1.GRU-PUB-NPU.pdf	Pdf
	datadict_v2.xsl	Other

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