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Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

ABSTRACT:

Mechanisms of acquired resistance to immune checkpoint inhibitors (ICIs) are poorly understood. The purpose of this study was to investigate whether alterations in genes encoding components of the HLA Class I antigen processing and presentation machinery or interferon signaling pathways play a role in acquired resistance to PD-1 or PD-L1 antagonistic antibodies. Whole exome sequencing was performed on tumor samples collected from patients with advanced non-small cell lung cancer at the time of resistance to PD-1 axis inhibitors and on available matched pre-treatment and normal samples. Patient-derived xenografts successfully established from the ICI-resistant samples were also exome sequenced. Additionally, RNA sequencing was performed on cases with sufficient tissue.

PROVIDER: phs001464 | dbGaP |

SECONDARY ACCESSION(S): PRJNA412284PRJNA412283

REPOSITORIES: dbGaP

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Dataset's files

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			Action	DRS
	GapExchange_phs001464.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001464.HLAClass1Antigen_LungCancer.v1.p1.MULTI.pdf	Pdf
	manifest_phs001464.HLAClass1Antigen_LungCancer.v1.p1.c2.DS-LCTC-MDS.pdf	Pdf
	datadict_v2.xsl	Other

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