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The Genetic and Transcriptomic Evolution of Melanoma

ABSTRACT:

The overarching goal of the study was to better understand the evolution of melanoma. To do this, we collected archival tissue of melanomas adjacent to their intact, remnant precursor lesions. We also collected archival tissue of primary melanomas and their matching metastases. From the formalin-fixed paraffin-embedded (FFPE) blocks, we microdissected non-neoplastic (normal), precursor, and descendent portions of tissue. Both RNA and DNA were extracted from the microdissected tissues and subjected to next generation sequencing. In summary, we performed matched DNA/RNA sequencing of melanoma/precursor/normal trios, allowing us to trace the genetic and transcriptomic evolution of melanoma.

PROVIDER: phs001550 | dbGaP |

REPOSITORIES: dbGaP

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Dataset's files

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			Action	DRS
	GapExchange_phs001550.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001550.MelanocyticNeoplasms.v1.p1.MULTI.pdf	Pdf
	manifest_phs001550.MelanocyticNeoplasms.v1.p1.c1.DS-M-NPU.pdf	Pdf
	datadict_v2.xsl	Other

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