Ontology highlight
ABSTRACT: Deep sequencing was performed to analyze the prevalence of somatic mutations during in vitro cell aging. Primary dermal fibroblasts from healthy subjects of young and advanced age, from Hutchinson-Gilford progeria syndrome, and from Xeroderma Pigmentosum complementation group A (XPA) and C (XPC), were first restricted in number and then expanded in vitro. DNA was obtained from cells pre- and post-expansion and sequenced at high depth, over a cumulative 290 kb target region, including the exons of 44 aging-related genes. Allele frequencies of 58 somatic mutations differed between the pre- and post-cell culture expansion passages.
REPOSITORIES: dbGaP
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GapExchange_phs001867.v1.p1.xml | Xml | |||
dbGaPEx2.1.5.xsd | Other | |||
Study_Report.phs001867.AgingCells.v1.p1.MULTI.pdf | ||||
manifest_phs001867.AgingCells.v1.p1.c1.GRU.pdf | ||||
datadict_v2.xsl | Other |
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