Genomic

Dataset Information

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Detection of Somatic Mutations In Vitro Aging Cells


ABSTRACT:

Deep sequencing was performed to analyze the prevalence of somatic mutations during in vitro cell aging. Primary dermal fibroblasts from healthy subjects of young and advanced age, from Hutchinson-Gilford progeria syndrome, and from Xeroderma Pigmentosum complementation group A (XPA) and C (XPC), were first restricted in number and then expanded in vitro. DNA was obtained from cells pre- and post-expansion and sequenced at high depth, over a cumulative 290 kb target region, including the exons of 44 aging-related genes. Allele frequencies of 58 somatic mutations differed between the pre- and post-cell culture expansion passages.

PROVIDER: phs001867 | dbGaP |

REPOSITORIES: dbGaP

Dataset's files

Source:
Action DRS
GapExchange_phs001867.v1.p1.xml Xml
dbGaPEx2.1.5.xsd Other
Study_Report.phs001867.AgingCells.v1.p1.MULTI.pdf Pdf
manifest_phs001867.AgingCells.v1.p1.c1.GRU.pdf Pdf
datadict_v2.xsl Other
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