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Effect of Remimazolam Co-induction and Maintenance on Postoperative Delirium In Older Patients Undergoing undergoing laparoscopic surgery: A Randomized Controlled Clinical Trial

ABSTRACT: Interventions: R Group:Anesthesia was induced and maintained by continuous intravenous pump injection of propofol remazolam.;P Group:Anesthesia was induced and maintained by continuous intravenous pump injection of propofol Primary outcome(s): Incidence of delirium within 3 days after surgery;Cognitive function status Study Design: Parallel

DISEASE(S): Patients Who Underwent Laparoscopic Radical Resection For Colorectal Cancer

PROVIDER: 117063 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Transcription profiling of human atrial tissue from patients undergoing coronary artery bypass graft surgery to determine the effect of anesthesia on gene expression

Project description:Anesthetic gases elicit organ protection in patients undergoing coronary artery bypass graft (CABG) surgery. This study aimed at identifying myocardial transcriptional phenotypes and anesthetic-induced changes in gene expression to predict cardiovascular biomarkers and cardiac function after off-pump CABG. Experiment Overall Design: Patients scheduled for off-pump CABG were randomized into a group with the anesthetic gas sevoflurane (n=10) or the intravenous anesthetic propofol (n=10). Atrial samples were collected at the beginning and end of bypass surgery to determine gene expression profiles.

2008-11-22 | E-GEOD-4386 | biostudies-arrayexpress

Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

Project description:The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.

| 2154097 | ecrin-mdr-crc

Disturbance of key cellular subproteomes upon propofol treatment is associated with increased permeability of the blood-brain barrier

Project description:Background: Propofol is a short-acting anesthetic, which is often used for induction and maintenance of general anesthesia, sedation for mechanically ventilated adults and procedural sedation. Several side effects of propofol are known and a substantial number of patients suffer from post-operative delirium after propofol application. In this study, we analyzed the effect of propofol on the function and protein expression profile on a proteome-wide scale. Methods: We cultured human brain microvascular endothelial cells in the absence and presence of propofol and analyzed the permeability of the blood-brain barrier (BBB) by fluorescein passage and protein expression on a proteome-wide scale by mass spectrometry. Results: Propofol interfered with the function of the blood-brain barrier. This was not due to de-creased adhesion of propofol-treated human brain microvascular endothelial cells. The proteomic analysis revealed that some key pathways in these cells were disturbed, such as oxygen metabolism, DNA damage recognition and response to stress. Conclusions: Propofol has strong effects on protein expression which could explain several side effects of propofol.

2022-10-13 | PXD033856 | Pride

Effects of Propofol Treatment in Neural Progenitors Derived from Human Induced Pluripotent Stem Cells

Project description:Propofol is an intravenous anesthetic that has been widely used in the clinical setting. Besides its anesthetic effects, propofol has been reported to influence the regulation of autonomic system. Controversies exist with regards to whether propofol exposure is safe for pregnant women and young children. The recent emergence of human induced pluripotent stem cells (hiPSCs) has provided a promising and theoretically inexhaustible source of neural progenitor cells (NPCs) for drug testing, which could be extended to in vitro experiments for anesthetics such as propofol. NPCs derived from three hiPSC lines, NES-GFP (a NESTIN-GFP reporter), USCK7 (iPSCs derived from urine derived cells), and ND2-0 (NIH), were treated with propofol at different concentrations (20, 50, 100 and 300 µM) for 6 h or 24 h. Early and late cell injury, cell proliferation and apoptosis were evaluated. Comparison of genome-wide gene expression profiles was performed for propofol-treated and untreated control iPSC-NPCs. Propofol treatment of NPCs for 6 h at the clinically relevant concentration (20 or 50 µM) did not affect cell viability, apoptosis, or proliferation, while propofol at higher concentration (100 or 300 µM) decreased NPC viability and induced apoptosis. Prolonged treatment of propofol for 24 h significantly decreased cell viability. In addition, 20 µM propofol treatment for 6 h did not alter global gene expression. Higher concentration of propofol exerted potential cytotoxicity via multiple cellular mechanisms. In summary, propofol treatment at commonly practiced clinical doses for 6 h did not have adverse effects on hiPSC-derived NPCs. In contrast, longer exposure and/or higher concentration of propofol treatment could decrease NPC viability and induce apoptosis.

2017-07-21 | GSE101724 | GEO

The effect of sub-anaesthetic dose of esketamine on postoperative fatigue of in patients after laparoscopic radical resection of colorectal cancer

Project description:Interventions: group K:a bolus injection of 0.1 mg/kg esketamine intravenously after anesthesia induction, followed by a continuous intravenous infusion of 0.1 mg/kg/h throughout the operation;group C:a bolus injection of 0.1 mg/kg normal saline intravenously after anesthesia induction, followed by a continuous intravenous infusion of 0.1 mg/kg/h throughout the operation Primary outcome(s): identity consequence fatigue scale Study Design: Parallel

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Protective effect of remote ischemic preconditioning combined with sevoflurane posttreatment on myocardial injury during laparoscopic radical resection of colorectal cancer

Project description:Interventions: total intravenous anesthesia:Propofol anesthesia;Sevoflurane posttreatment:Sevoflurane anesthesia;Propofol combined with sevoflurane anesthesia:Propofol combined with sevoflurane anesthesia;RIPC and propofol anesthesia:Remote ischemic preconditioning and propofol anesthesia;RIPC and sevoflurane posttreatment:Remote ischemic preconditioning and sevoflurane anesthesia;RIPC and propofol combined with sevoflurane anesthesia:Remote ischemic preconditioning and propofol combined with sevoflurane anesthesia Primary outcome(s): blood pressure;heart rate;SPO2%;Blood gas analysis;Central venous pressure;H-FABP;cTnI;TNF-a;IL-8 Study Design: Parallel

| 2703482 | ecrin-mdr-crc

Effects of TAPB and flurbiprofen axetil on postoperative recovery in elderly patients undergoing colorectal surgery: a randomized, controlled trial of 2x2-factorial design

Project description:Interventions: TAPB:continue TAPB perioperaitive;The flurbiprofen group:Continuous infusion of flurbiprofen by postoperative analgesic pump;TAPB+flurbiprofen group:Continuous intraoperative and postoperative TAPB and continuous intravenous analgesic pump infusion of flurbiprofen Primary outcome(s): The incidence of chronic pain after operation;Incidence of postoperative cognitive dysfunction Study Design: Case-Control study

| 2680085 | ecrin-mdr-crc

Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery

Project description:Objectives: To compare free-opioid anesthesia (the combination of epidural anesthesia, intravenous lidocaine, ketamine, propofol, and sevoflurane) and opioid anesthesia (fentanyl, propofol and sevoflurane) regarding intraoperative analgesic efficacy in colectomies and rectal resections at Viet Tiep Friendship Hospital. Methods: A prospective, randomized controlled clinical trial was performed on 98 patients who were anesthetized for colorectal surgery from December 2019 to November 2021. Patients were randomized into 2 groups: Group OA - Opioid anesthesia (n = 49): Intraoperative pain control by fentanyl; FOA group - Free-opioid anesthesia (n = 49): Intraoperative pain control by continuous infusion of lidocaine, bolus doses of ketamine combined with epidural levobupivacaine.

| 92384 | ecrin-mdr-crc

Expression data from glioblastoma surgical specimens

Project description:Surgical resection is the first choice of the standardized treatment scheme for glioblastoma and is performed under general anesthesia. Previous researches have shown that propofol and sevoflurane have different effects on the biological process of glioma cells from the molecular level. Some of them, for instance, control the glioma cell proliferation, invasion and migration In vitro or In vivo. We used mRNA microarray to discuss the effects of propofol and sevoflurane on gene expression in patients with glioblastoma. The correlation between DEGs and patients’ prognosis was further analyzed.

2021-06-28 | GSE179004 | GEO

Effects of different administration methods of remimazolam on hemodynamics during induction of general anesthesia in patients with colorectal cancer

Project description:Interventions: Group Control:Intravenous propofol;Group1:Remidazolam 0.3mg/kg i.v;Group2:Remazolam 6mg/kg/h by intravenous pump;Group3:Remidazolam 12mg/kg/h by intravenous pump Primary outcome(s): systolic arterial pressure;arterial diastolic pressure;Mean arterial pressure;Heart rate Study Design: Parallel

| 88222 | ecrin-mdr-crc

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