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Population screening for colorectal cancer by colonoscopy or CT-colonography in the Netherlands.

ABSTRACT: Interventions: For this study, 7500 persons will be invited and randomized (1:1:1) in three different arms: 1. CT-colonography (2500 individuals); 2. Colonoscopy and preliminary interview by phone (2500 individuals); 3. Colonoscopy and preliminary interview at outpatient clinic (2500 individuals). Furthermore, an extra number of 10.000 persons will be randomized for the NORDICC trial (this trial will be registered separately). These persons will not be invited to participate in the screening program. The primary outcome of this study is the participation rate. The expected participation rate for the respective separate arms is 35 %, 27,5 % and 22,5 %. Consequently, a total number of 1250 colonoscopies and 875 CT-colonographies is expected. To allow sufficient certainty, we will continue the study until the target number of 1250 colonoscopies and 875 CT-colonographies is reached. Primary outcome(s): Evaluation of the participation rate of a population-based screening program by colonoscopy or CT-colonography in the Netherlands. Study Design: Randomized controlled trial, Open (masking not used), Active, Parallel

DISEASE(S): Colorectal Cancer, Adenomatous Polyps, Screening, Colonoscopy, Ct-colonography

PROVIDER: 16140 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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