Flat colorectal cancer precursor lesions: epidemiological aspects and molecular analysis.

ABSTRACT: Interventions: 1. Clinical data registration; 2. Molecular analysis of polypoid vs. flat colorectal lesions. Primary outcome(s): 1. Prevalence of flat colorectal lesions in a Dutch population; 2. Clinical characteristics (e.g. location of lesions, percentage of high-grade dysplasia or early cancer); 3. Molecular charcteristics (epigenetic: methylation status and genetic) of flat vs. polypoid colorectal lesions; 4. Prevalence of flat advanced colorectal cancers vs. polypoid advanced colorecal cancers: clinical features of these lesions (e.g. tumor stage); 5. Relation between serrated and adenomatous polyps. Study Design: Non-randomized controlled trial, Open (masking not used), N/A , unknown, Factorial

DISEASE(S): Colorectal Cancer, Precursor Lesions, Adenoma, Flat, Non-polypoid, High-risk Population, Family History Of Colorectal Cancer

PROVIDER: 16199 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR