Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer

ABSTRACT: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the growth of the tumor. Combining more than one drug with interferon-gamma may kill more tumor cells. This phase I/II trial is studying the side effects and best dose of giving fluorouracil together with phenylbutyrate, indomethacin, and interferon-gamma and to see how well it works in treating patients with stage IV colorectal cancer

DISEASE(S): Adenocarcinoma,Stage Ivb Colon Cancer,Signet Ring Adenocarcinoma Of The Rectum,Recurrent Colon Cancer,Rectal Neoplasms,Cystadenocarcinoma,Stage Iva Rectal Cancer,Signet Ring Adenocarcinoma Of The Colon,Stage Ivb Rectal Cancer,Adenocarcinoma, Mucinous,Mucinous Adenocarcinoma Of The Colon,Recurrent Rectal Cancer,Colonic Neoplasms,Stage Iva Colon Cancer,Mucinous Adenocarcinoma Of The Rectum

PROVIDER: 2002426 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR