Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu

ABSTRACT: Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person’s white blood cells to kill cancer cells. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Phase I trial to study the effectiveness of interleukin-12 and trastuzumab in treating patients who have cancer that has high levels of HER2/neu and has not responded to previous therapy

DISEASE(S): Stage Iv Colon Cancer,Recurrent Gallbladder Cancer,Stage Iv Rectal Cancer,Thyroid Neoplasms,Stage Ivb Vulvar Cancer,Stage Iv Breast Cancer,Stage Iii Adenoid Cystic Carcinoma Of The Oral Cavity,Urinary Bladder Neoplasms,Endometrial Neoplasms,Breast Neoplasms,Recurrent Small Intestine Cancer,Stage Iv Follicular Thyroid Cancer,Stage Iii Salivary Gland Cancer,Recurrent Colon Cancer,Localized Unresectable Adult Primary Liver Cancer,Fallopian Tube Neoplasms,Recurrent Breast Cancer,Urethral Cancer Associated With Invasive Bladder Cancer,Recurrent Rectal Cancer,Stomach Neoplasms,Recurrent Extrahepatic Bile Duct Cancer,Stage Iii Esophageal Cancer,Metastatic Transitional Cell Cancer Of The Renal Pelvis And Ureter,Salivary Gland Neoplasms,Recurrent Malignant Testicular Germ Cell Tumor,Stage Iii Bladder Cancer,Kidney Neoplasms,Recurrent Gastric Cancer,Vaginal Neoplasms,Stage Iii Prostate Cancer,Adrenocortical Carcinoma,Carcinoma, Medullary,Stage Iiib Breast Cancer,Gastrinoma,Thyroid Diseases,Somatostatinoma,Stage Iiib Anal Cancer,Squamous Cell Carcinoma Of Head And Neck,Stage Iiia Anal Cancer,Rectal Neoplasms,Liver Metastases,Stage Iii Ovarian Epithelial Cancer,Stage Ivb Cervical Cancer,Mucoepidermoid Tumor,Advanced Adult Primary Liver Cancer,Stage Iv Endometrial Carcinoma,Recurrent Gastrointestinal Carcinoid Tumor,Oropharyngeal Neoplasms,Testicular Neoplasms,Stage Iva Cervical Cancer,Recurrent Pancreatic Cancer,Gastrointestinal Neoplasms,Distal Urethral Cancer,Fallopian Tube Cancer,Liver Neoplasms,Breast Neoplasms, Male,Recurrent Squamous Cell Carcinoma Of The Oropharynx,Lung Neoplasms,Malignant Pericardial Effusion,Stage Iii Papillary Thyroid Cancer,Recurrent Prostate Cancer,Prostatic Neoplasms,Stage Iiia Non-small Cell Lung Cancer,Stage Iv Squamous Cell Carcinoma Of The Nasopharynx,Stage Iii Gastric Cancer,Neoplasms, Germ Cell And Embryonal,Lung Metastases,Carcinoma, Mucoepidermoid,Recurrent Adult Primary Liver Cancer,Stage Iii Malignant Testicular Germ Cell Tumor,Stage Iiib Non-small Cell Lung Cancer,Recurrent Adrenocortical Carcinoma,Recurrent Ovarian Epithelial Cancer,Metastatic Gastrointestinal Carcinoid Tumor,Stage Iv Squamous Cell Carcinoma Of The Lip And Oral Cavity,Parathyroid Neoplasms,Stage Iii Pancreatic Cancer,Recurrent Cervical Cancer,Neoplasms, Unknown Primary,Stage Iv Squamous Cell Carcinoma Of The Larynx,Stage Iii Follicular Thyroid Cancer,Metastatic Parathyroid Cancer,Carcinoma, Adenoid Cystic,Stage Iii Squamous Cell Carcinoma Of The Lip And Oral Cavity,Stage Iv Adrenocortical Carcinoma,Inflammatory Breast Cancer,Malignant Pleural Effusion,Male Breast Cancer,Recurrent Endometrial Carcinoma,Pericardial Effusion,Urethral Neoplasms,Recurrent Squamous Cell Carcinoma Of The Nasopharynx,Recurrent Esophageal Cancer,Unresectable Gallbladder Cancer,Gallbladder Neoplasms,Bile Duct Neoplasms,Carcinoma, Islet Cell,Stage Iii Mucoepidermoid Carcinoma Of The Oral Cavity,Stage Iv Renal Cell Cancer,Primary Peritoneal Cavity Cancer,Carcinoma,Pleural Effusion,Carcinoma, Transitional Cell,Thyroid Carcinoma, Anaplastic,Recurrent Anal Cancer,Recurrent Salivary Gland Cancer,Stage Iii Squamous Cell Carcinoma Of The Larynx,Recurrent Vaginal Cancer,Recurrent Mucoepidermoid Carcinoma Of The Oral Cavity,Recurrent Parathyroid Cancer,Vulvar Neoplasms,Stage Ivb Vaginal Cancer,Occult Non-small Cell Lung Cancer,Pulmonary Carcinoid Tumor,Neoplasm Metastasis,Stage Iv Prostate Cancer,Esophageal Neoplasms,Stage Iv Papillary Thyroid Cancer,Carcinoma, Renal Cell,Vipoma,Recurrent Transitional Cell Cancer Of The Renal Pelvis And Ureter,Unresectable Extrahepatic Bile Duct Cancer,Recurrent Bladder Cancer,Skin Metastases,Proximal Urethral Cancer,Nasopharyngeal Carcinoma,Carcinoid Tumor,Laryngeal Neoplasms,Stage Iv Gastric Cancer,Carcinoma Of The Appendix,Recurrent Squamous Cell Carcinoma Of The Lip And Oral Cavity,Small Intestine Adenocarcinoma,Thyroid Cancer, Papillary,Carcinoma, Squamous Cell,Recurrent Adenoid Cystic Carcinoma Of The Oral Cavity,Stage Iii Rectal Cancer,Recurrent Thyroid Cancer,Inflammatory Breast Neoplasms,Stage Iii Endometrial Carcinoma,Bone Metastases,Stage Iv Ovarian Epithelial Cancer,Stage Iv Squamous Cell Carcinoma Of The Oropharynx,Intestinal Neoplasms,Newly Diagnosed Carcinoma Of Unknown Primary,Recurrent Renal Cell Cancer,Stage Iii Colon Cancer,Uterine Cervical Neoplasms,Stage Iii Squamous Cell Carcinoma Of The Oropharynx,Stage Iiia Breast Cancer,Anaplastic Thyroid Cancer,Insulinoma,Recurrent Urethral Cancer,Stage Iv Bladder Cancer,Recurrent Non-small Cell Lung Cancer,Stage Iii Squamous Cell Carcinoma Of The Nasopharynx,Thyroid Gland Medullary Carcinoma,Stage Iv Mucoepidermoid Carcinoma Of The Oral Cavity,Malignant Carcinoid Syndrome,Stage Iii Cervical Cancer,Recurrent Carcinoma Of Unknown Primary,Ureteral Neoplasms,Pleural Effusion, Malignant,Stage Iv Esophageal Cancer,Carcinoma, Non-small-cell Lung,Recurrent Vulvar Cancer,Pancreatic Neoplasms,Stage Iva Vaginal Cancer,Cholangiocarcinoma,Stage Iii Adrenocortical Carcinoma,Stage Iv Salivary Gland Cancer,Stage Iii Vaginal Cancer,Pancreatic Polypeptide Tumor,Laryngeal Diseases,Stage Iv Anal Cancer,Stage Iv Pancreatic Cancer,Anus Neoplasms,Stage Iv Non-small Cell Lung Cancer,Stage Iv Adenoid Cystic Carcinoma Of The Oral Cavity,Adenocarcinoma, Follicular,Recurrent Islet Cell Carcinoma,Stage Iii Vulvar Cancer,Carcinoma, Ovarian Epithelial,Glucagonoma,Stage Iii Renal Cell Cancer,Recurrent Squamous Cell Carcinoma Of The Larynx,Wdha Syndrome,Colonic Neoplasms

PROVIDER: 2003507 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR