7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)

ABSTRACT: This phase I trial is studying the side effects and best dose of giving 7-hydroxystaurosporine together with irinotecan hydrochloride in treating patients with metastatic or unresectable solid tumors, including triple-negative breast cancer (currently enrolling only patients with triple-negative breast cancer since 6/8/2007). Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving 7-hydroxystaurosporine together with irinotecan hydrochloride may help kill more cancer cells by making tumor cells more sensitive to the drug.

DISEASE(S): Recurrent Gallbladder Cancer,Stage Iv Colon Cancer,Granuloma,Ovarian Sarcoma,Stage Iv Rectal Cancer,Stage Iv Breast Cancer,Head And Neck Neoplasms,Endometrial Neoplasms,Breast Neoplasms,Recurrent Small Intestine Cancer,Neoplasms,Recurrent Colon Cancer,Recurrent Breast Cancer,Stage Iv Borderline Ovarian Surface Epithelial-stromal Tumor,Recurrent Extrahepatic Bile Duct Cancer,Recurrent Rectal Cancer,Stomach Neoplasms,Stage Iv Inverted Papilloma Of The Paranasal Sinus And Nasal Cavity,Recurrent Lymphoepithelioma Of The Oropharynx,Salivary Gland Neoplasms,Recurrent Gastric Cancer,Stage Iv Squamous Cell Carcinoma Of The Paranasal Sinus And Nasal Cavity,Stage Iv Esthesioneuroblastoma Of The Paranasal Sinus And Nasal Cavity,Stage Iv Ovarian Germ Cell Tumor,Stage Iv Verrucous Carcinoma Of The Oral Cavity,Squamous Cell Carcinoma Of Head And Neck,Rectal Neoplasms,Leiomyosarcoma,Mucoepidermoid Tumor,Stage Ivb Cervical Cancer,Advanced Adult Primary Liver Cancer,Stage Iv Basal Cell Carcinoma Of The Lip,Stage Iv Endometrial Carcinoma,Recurrent Gastrointestinal Carcinoid Tumor,Oropharyngeal Neoplasms,Stage Iv Squamous Cell Carcinoma Of The Hypopharynx,Stage Iva Cervical Cancer,Recurrent Pancreatic Cancer,Ovarian Stromal Cancer,Gastrointestinal Neoplasms,Triple Negative Breast Neoplasms,Recurrent Inverted Papilloma Of The Paranasal Sinus And Nasal Cavity,Triple-negative Breast Cancer,Liver Neoplasms,Recurrent Squamous Cell Carcinoma Of The Oropharynx,Lung Neoplasms,Small Intestine Leiomyosarcoma,Unspecified Adult Solid Tumor, Protocol Specific,Recurrent Prostate Cancer,Prostatic Neoplasms,Stage Iv Squamous Cell Carcinoma Of The Nasopharynx,Recurrent Esthesioneuroblastoma Of The Paranasal Sinus And Nasal Cavity,Recurrent Lymphoepithelioma Of The Nasopharynx,Neoplasms, Germ Cell And Embryonal,Carcinoma, Mucoepidermoid,Recurrent Adult Primary Liver Cancer,Recurrent Ovarian Epithelial Cancer,Metastatic Gastrointestinal Carcinoid Tumor,Stage Iv Squamous Cell Carcinoma Of The Lip And Oral Cavity,Recurrent Cervical Cancer,Neoplasms, Unknown Primary,Stage Iv Squamous Cell Carcinoma Of The Larynx,Carcinoma, Adenoid Cystic,Gastrointestinal Stromal Tumor,Progesterone Receptor-negative Breast Cancer,Recurrent Endometrial Carcinoma,Recurrent Squamous Cell Carcinoma Of The Nasopharynx,Recurrent Esophageal Cancer,Unresectable Gallbladder Cancer,Gallbladder Neoplasms,Bile Duct Neoplasms,Recurrent Midline Lethal Granuloma Of The Paranasal Sinus And Nasal Cavity,Carcinoma, Verrucous,Gastrointestinal Stromal Tumors,Stage Iv Midline Lethal Granuloma Of The Paranasal Sinus And Nasal Cavity,Carcinoma,Recurrent Squamous Cell Carcinoma Of The Hypopharynx,Recurrent Anal Cancer,Recurrent Salivary Gland Cancer,Recurrent Squamous Cell Carcinoma Of The Paranasal Sinus And Nasal Cavity,Stage Iv Lymphoepithelioma Of The Oropharynx,Recurrent Mucoepidermoid Carcinoma Of The Oral Cavity,Small Intestine Lymphoma,Stage Iv Lymphoepithelioma Of The Nasopharynx,Stage Iv Prostate Cancer,Esophageal Neoplasms,Esthesioneuroblastoma, Olfactory,Recurrent Metastatic Squamous Neck Cancer With Occult Primary,Recurrent Ovarian Germ Cell Tumor,Unresectable Extrahepatic Bile Duct Cancer,Nasopharyngeal Carcinoma,Carcinoid Tumor,Laryngeal Neoplasms,Stage Iv Gastric Cancer,Small Cell Lung Carcinoma,Carcinoma Of The Appendix,Recurrent Squamous Cell Carcinoma Of The Lip And Oral Cavity,Small Intestine Adenocarcinoma,Recurrent Adenoid Cystic Carcinoma Of The Oral Cavity,Carcinoma, Squamous Cell,Germinoma,Stage Iv Ovarian Epithelial Cancer,Stage Iv Squamous Cell Carcinoma Of The Oropharynx,Intestinal Neoplasms,Extensive Stage Small Cell Lung Cancer,Recurrent Basal Cell Carcinoma Of The Lip,Her2-negative Breast Cancer,Uterine Cervical Neoplasms,Carcinoma, Basal Cell,Recurrent Non-small Cell Lung Cancer,Estrogen Receptor-negative Breast Cancer,Stage Iv Mucoepidermoid Carcinoma Of The Oral Cavity,Malignant Carcinoid Syndrome,Paranasal Sinus Neoplasms,Stage Iv Esophageal Cancer,Carcinoma, Non-small-cell Lung,Papilloma, Inverted,Ovarian Neoplasms,Recurrent Verrucous Carcinoma Of The Oral Cavity,Pancreatic Neoplasms,Recurrent Borderline Ovarian Surface Epithelial-stromal Tumor,Cholangiocarcinoma,Stage Iv Salivary Gland Cancer,Stage Iv Anal Cancer,Laryngeal Diseases,Recurrent Verrucous Carcinoma Of The Larynx,Stage Iv Pancreatic Cancer,Anus Neoplasms,Stage Iv Non-small Cell Lung Cancer,Stage Iv Adenoid Cystic Carcinoma Of The Oral Cavity,Untreated Metastatic Squamous Neck Cancer With Occult Primary,Brenner Tumor,Stage Iv Verrucous Carcinoma Of The Larynx,Carcinoma, Ovarian Epithelial,Papilloma,Recurrent Small Cell Lung Cancer,Recurrent Squamous Cell Carcinoma Of The Larynx,Colonic Neoplasms

PROVIDER: 2007227 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR