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Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent Colorectal Cancer

ABSTRACT: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, fluorouracil, and capecitabine, work in different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or deliver cancer-killing substances to them. Combining chemotherapy with monoclonal antibody therapy may kill more tumor cells. It is not yet known which combination chemotherapy regimen with bevacizumab works better in treating colorectal cancer. This randomized phase III trial is studying giving two different combination chemotherapy regimens together with bevacizumab and comparing how well they work in treating patients with locally advanced, metastatic, or recurrent colorectal cancer

DISEASE(S): Stage Iv Colon Cancer,Adenocarcinoma,Stage Iii Colon Cancer,Recurrent Colon Cancer,Stage Iii Rectal Cancer,Rectal Neoplasms,Stage Iv Rectal Cancer,Adenocarcinoma Of The Rectum,Adenocarcinoma Of The Colon,Recurrent Rectal Cancer,Colonic Neoplasms

PROVIDER: 2009912 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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