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Dasatinib in Treating Patients With Previously Treated Metastatic Colorectal Cancer

ABSTRACT: This phase II trial is studying dasatinib to see how well it works in treating patients with previously treated metastatic colorectal cancer. Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for their growth.

DISEASE(S): Stage Iv Colon Cancer,Recurrent Colon Cancer,Rectal Neoplasms,Stage Iv Rectal Cancer,Recurrent Rectal Cancer,Colonic Neoplasms

PROVIDER: 2042300 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Expression data from a reversible dasatinib-resistant state in long-term dasatinib-treated c-KIT-mutated Kasumi-1 cell line

2013-11-27 | GSE39073 | GEO

Expression data from a reversible dasatinib-resistant state in long-term dasatinib-treated c-KIT-mutated Kasumi-1 cell line

Project description:Long-term treatment of Kasumi-1 cells at clinically attained doses of dasatinib led to decreased drug-sensitivity by means of IC50 values (relative to treatment-naive cells). Changes were paralled by profound alterations in c-KIT expression and cell signaling signatures. Upon brief discontinuation of dasatinib treatment, these alterations reversed and drug sensitivity was restored. We used gene expression profiling to examine reversal of dasatinib-resistance at the molecular/expression level. Kasumi-1 cells were either treated with dasatinib for 12 weeks (R48) or left untreated (K). Subsequently, dasatinib was withdrawn from R48 cells for 1 week (PR48). RNA was extracted from R48 and K cells and hybridized on Affymetrix microarrays after 12 weeks and PR48 after a total time span of 13 weeks.

2013-11-27 | E-GEOD-39073 | biostudies-arrayexpress

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