Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome
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ABSTRACT: RATIONALE: The use of intrauterine levonorgestrel may prevent atypical endometrial hyperplasia and endometrial cancer in women with hereditary non-polyposis colorectal cancer or Lynch syndrome. It is not yet known whether intrauterine levonorgestrel and observation are more effective than observation alone in preventing atypical endometrial hyperplasia and endometrial cancer in women with hereditary non-polyposis colorectal cancer or Lynch syndrome.
PURPOSE: This randomized phase III trial is studying intrauterine levonorgestrel and observation to see how well they work compared with observation alone in preventing atypical endometrial hyperplasia and endometrial cancer in women with hereditary non-polyposis colorectal cancer or Lynch syndrome.
DISEASE(S): Endometrial Cancer,Lynch Syndrome,Atypical Endometrial Hyperplasia (aeh) And Carcinoma,Hereditary Non-polyposis Colon Cancer (hmsh2, Hmlh1, Hpms1, Hpms2),Endometrial Cancer/tumours In Women With Hereditary Non-polyposis Colorectal Cancer (hnpcc),Endometrial Neoplasms,Colorectal Neoplasms, Hereditary Nonpolyposis,Colonic Neoplasms
PROVIDER: 2047003 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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