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Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors

ABSTRACT: RATIONALE: Sorafenib and pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sorafenib may also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sorafenib together with pemetrexed and cisplatin may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of sorafenib when given together with pemetrexed and cisplatin in treating patients with advanced solid tumors.

DISEASE(S): Lung Cancer,Sarcoma,Colorectal Cancer,Mesothelioma,Prostate Cancer,Head And Neck Cancer,Pancreatic Cancer,Breast Cancer

PROVIDER: 2057338 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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