Dataset Information

Colon Cancer Prevention Study

ABSTRACT: The goal of this research study is to design messages which can help people learn more about how to prevent colon cancer. Eligible participants will be asked to review a series of short cancer prevention messages and share their opinions on them. Participants also need to fill out a short survey with questions on their background and attitudes and knowledge about physical activity and colon cancer. The whole study can be completed online and will take less than 1 hour. After completing the entire study, participants will receive $25. If you are interested in participating in this study, please visit the following website: https://surveys.chaicore.com/preventcancer/

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms,Cancer

PROVIDER: 2074038 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Background and study aims Breast and colorectal cancers are two major health problems in developed countries, accounting for nearly 27% of the 3.2 million cancer cases diagnosed in the EU. The majority of people with cancer will receive chemotherapy as part of their treatment and, thus, are likely to suffer chemotherapy-related side effects. Close follow-up and management of such adverse events are of great importance to avoid further and more severe complications in these patients. Thanks to advances in chemotherapy treatment, patients usually stay in their homes while receiving treatment. Side effects are thus dealt with by family caregivers and patients themselves, often with very little support from health professionals. The remote follow-up of chemotherapy-related side effects by means of mobile phones or computers may help these patients reduce the severity of complications by identifying and controlling them earlier and easier. The aim of this study is to find out if the use of a new Web program installed in mobile phones can help cancer patients receiving chemotherapy to better control the side effects of the treatment. The researchers hope to learn more about how this mobile phone-supported system affects the control of side effects, patients’ quality of life, number of hospital admissions, and visits to the emergency department. Besides, the researchers hope to find out if patients and health professionals feel comfortable using this new electronic communication system. Who can participate? Patients aged 15 or over with breast or colorectal cancer who are about to start a new chemotherapy treatment What does the study involve? All participants fill in three short questionnaires at the beginning of the study. It takes around 15 minutes to fill in all the questionnaires. Participants are randomly allocated to either use the phone system or to receive the usual medical care. Participants in the phone group are trained on the use of the phone system. Twice a day they fill in a short questionnaire on side effects using their mobile phone or PC. According to the symptoms they report, text messages or videos are sent back to them. Should the symptoms become serious, a nurse contacts them. They also receive the usual medical care. Additionally, participants may be selected for an interview with a member of the scientific team at the beginning and at the end of the study. Participants also fill in three more questionnaires at specific times during the study.

Project description:MicroRNAs (miRNAs) are abundant in the circulation and play a central role in diverse biological processes; they may be useful for early diagnosis of hepatocellular carcinoma (HCC). We conducted a two-phase, case-control study (20 pairs for the discovery set and 49 pairs for the validation set) to test the hypothesis that genome-wide dysregulation of circulating miRNAs differentiate HCC cases from controls. Taqman low density arrays were used to examine genome-wide miRNA expression for the discovery set, and quantitative RT-PCR was used to validate candidate miRNAs for both discovery and validation sets. Sixty-six miRNAs were found to be significantly over-expressed in plasma of HCC cases compared to controls after adjusting for false discovery rate (p<0.05). A volcano plot indicated that 7 miRNAs had greater than 2-fold case-control differences with p<0.01. Four significant miRNAs (miR-150, miR-30c, miR-483-5p and miR-520b) detectable in all samples with varied expression levels were further validated in a validation set. MiR-483-5p was statistically significantly over-expressed in HCC cases compared with controls (3.20 vs. 0.82, p<0.0001). HCC risk factors and clinic-pathological characteristics did not influence miR-483-5p expression. The combination of plasma miR-483-5p level and HCV status can significantly differentiate HCC cases from controls with an AUC of 0.908 (p<0.0001). The sensitivity and specificity were, respectively, 75.5% and 89.8%. These preliminary results suggest the importance of dysregulated circulating miR-483-5p as a potential HCC biomarker. Confirmation of aberrant expression of miR-483-5p in a large prospective HCC study will provide support for its application to HCC detection. A hospital-based HCC case-control study including 20 HCC patients and 20 controls is conducted in Columbia University Medical Center (CUMC), which is approved by the Institutional Review Board. Cases were newly diagnosed HCC patients who were treated in the Hepatobiliary Oncology Clinics, CUMC, and examined pathologically. Controls were recruited from volunteers through the Research Recruitment and Minority Outreach (RRMO) core of Herbert Irving Comprehensive Cancer Center (HICCC). Flyers were placed at strategic locations around CUMC where hospital visitors and employees frequent or were handed out at inreach events at the hospital or at outreach events in the community. Interested participants were directed to contact the trained recruitment staff from the RRMO and given further information about participation. Interested participants were excluded from the control group if diagnosed for any kind of cancer or liver disease. Eligible controls were asked to fill out the same demographic and epidemiological questionnaire as HCC cases. In the current study, controls were matched with HCC cases on age (M-BM-15 yrs), gender (male/female) and ethnicities (Caucasian/Hispanic/African-American/Asian).

Dataset Information

Colon Cancer Prevention Study

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