RO4929097 and Capecitabine in Treating Patients With Refractory Solid Tumors

ABSTRACT: This phase I clinical trial is studying the side effects and best dose of RO4929097 when given together with capecitabine in treating patients with refractory solid tumors. RO4929097 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving RO4929097 together with chemotherapy may kill more tumor cells.

DISEASE(S): Stage Iv Colon Cancer,Adult Grade Iii Lymphomatoid Granulomatosis,Stage Iv Rectal Cancer,Lymphoma, Large-cell, Immunoblastic,Lymphoproliferative Disorders,Stage Iv Breast Cancer,Breast Neoplasms,Stage Iv Adult Diffuse Mixed Cell Lymphoma,Stage Iv Adult Immunoblastic Large Cell Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Recurrent Colon Cancer,Recurrent Breast Cancer,Mycosis Fungoides,Stage Iv Adult Lymphoblastic Lymphoma,Recurrent Rectal Cancer,Aids-related Peripheral/systemic Lymphoma,Stage Iii Adult Burkitt Lymphoma,Aids-related Lymphoblastic Lymphoma,Recurrent Adult Burkitt Lymphoma,Leukemia, T-cell,Lymphomatoid Granulomatosis,Lymphoma, T-cell, Peripheral,Stage Iv Mycosis Fungoides/sezary Syndrome,Stage Iiib Breast Cancer,Lymphoma, B-cell, Marginal Zone,Rectal Neoplasms,Nodal Marginal Zone B-cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Lymphoma, T-cell, Cutaneous,Stage Iv Adult Burkitt Lymphoma,Stage Iii Adult T-cell Leukemia/lymphoma,Stage Iii Adult Diffuse Large Cell Lymphoma,Waldenstrom Macroglobulinemia,Lymphoma, Follicular,Recurrent Mantle Cell Lymphoma,Stage Iii Cutaneous T-cell Non-hodgkin Lymphoma,Leukemia,Hodgkin Disease,Recurrent Adult Hodgkin Lymphoma,Mycoses,Recurrent Adult Lymphoblastic Lymphoma,Breast Neoplasms, Male,Unspecified Adult Solid Tumor, Protocol Specific,Lymphoma, T-cell,Stage Iv Grade 3 Follicular Lymphoma,Immunoblastic Lymphadenopathy,Male Breast Cancer,Recurrent Adult Diffuse Mixed Cell Lymphoma,Stage Iv Grade 2 Follicular Lymphoma,Recurrent Adult T-cell Leukemia/lymphoma,Stage Iv Cutaneous T-cell Non-hodgkin Lymphoma,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Lymphoma, Large B-cell, Diffuse,Stage Iv Adult T-cell Leukemia/lymphoma,Stage Iv Adult Diffuse Large Cell Lymphoma,Small Intestine Lymphoma,Stage Iiic Breast Cancer,Sezary Syndrome,Adult Nasal Type Extranodal Nk/t-cell Lymphoma,Splenic Marginal Zone Lymphoma,Lymphoma, Mantle-cell,Leukemia-lymphoma, Adult T-cell,Stage Iii Adult Diffuse Small Cleaved Cell Lymphoma,Recurrent Adult Immunoblastic Large Cell Lymphoma,Stage Iv Grade 1 Follicular Lymphoma,Stage Iv Mantle Cell Lymphoma,Primary Central Nervous System Non-hodgkin Lymphoma,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Aids-related Primary Cns Lymphoma,Burkitt Lymphoma,Stage Iii Mycosis Fungoides/sezary Syndrome,Hiv-associated Hodgkin Lymphoma,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Stage Iii Grade 1 Follicular Lymphoma,Stage Iii Adult Immunoblastic Large Cell Lymphoma,Post-transplant Lymphoproliferative Disorder,Stage Iii Marginal Zone Lymphoma,Stage Iii Rectal Cancer,Stage Iii Adult Diffuse Mixed Cell Lymphoma,Recurrent Marginal Zone Lymphoma,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Aids-related Diffuse Small Cleaved Cell Lymphoma,Leukemia, Lymphocytic, Chronic, B-cell,Intraocular Lymphoma,Recurrent Grade 3 Follicular Lymphoma,Stage Iii Colon Cancer,Her2-negative Breast Cancer,Stage Iii Adult Hodgkin Lymphoma,Stage Iiia Breast Cancer,Primary Central Nervous System Hodgkin Lymphoma,Stage Iii Grade 2 Follicular Lymphoma,Waldenström Macroglobulinemia,Angioimmunoblastic T-cell Lymphoma,Stage Iv Marginal Zone Lymphoma,Aids-related Immunoblastic Large Cell Lymphoma,Lymphoma, Large-cell, Anaplastic,Stage Iv Adult Hodgkin Lymphoma,Stage Iii Mantle Cell Lymphoma,Stage Iii Grade 3 Follicular Lymphoma,Stage Iv Adult Diffuse Small Cleaved Cell Lymphoma,Precursor Cell Lymphoblastic Leukemia-lymphoma,Recurrent Cutaneous T-cell Non-hodgkin Lymphoma,Aids-related Diffuse Large Cell Lymphoma,Stage Iv Small Lymphocytic Lymphoma,Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Aids-related Small Noncleaved Cell Lymphoma,Anaplastic Large Cell Lymphoma,Stage Iii Small Lymphocytic Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Stage Iii Adult Lymphoblastic Lymphoma,Aids-related Diffuse Mixed Cell Lymphoma,Cutaneous B-cell Non-hodgkin Lymphoma,Colonic Neoplasms

PROVIDER: 2091768 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR