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AlloStim In-Situ Vaccine in Pre-Treated Metastatic Colorectal Cancer

ABSTRACT: This is a personalized anti-cancer vaccine protocol which includes an in-situ (in the body) cancer vaccine step which combines killing a single metastatic tumor lesion by use of cryoablation in order to cause the release of tumor-specific markers to the immune system and then injecting bioengineered allogeneic immune cells (AlloStim) into the lesion as an adjuvant in order to modulate the immune response and educate the immune system to kill other tumor cells where ever they reside in the body.

DISEASE(S): Metastatic Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2136197 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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AlloStim Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer

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Wilson2012 - tumor vaccine efficacy

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Bianca2012 - Mathematical modeling of the immune system recognition to mammary carcinoma antigen

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Project description:Whole blood transcriptomics analysis of healthy individuals, immunized with the MVA-B vaccine via transcutaneous or intramuscular route. We define an early gene expression profile, detected at day 1 and day 7 after immunization, that is associated with the development of either MVA specific humoral or CD8 T cell responses. We used System Biology approach to analyse vaccine efficacy in order to find innate predictive biomarkers of the quality of adaptive responses for potential clinical use in the future. Moreover, from a methodological point of view this study increases knowledges on how vaccine route(s) can affect resulting immune responses and into mechanisms involved in the induction of humoral and cellular immunity to vaccine.

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