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Pilot-study: Non-thermal Ablation Using Irreversible Electroporation to Treat Colorectal Liver Metastases

ABSTRACT: Irreversible electroporation is a new, minimal-invasive image-guided treatment to treat tumors near or around vulnerable structures, such as central liver tumors. To investigate the safety and efficacy of IRE in the treatment of colorectal liver metastases, patients with resectable colorectal liver metastases undergo IRE and resection of the metastases in the same session. After resection, the specimen is examined macroscopically to determine vitality using a specific vitality staining (triphenyl-tetrazoliumchloride) and to visualize the exact ablation zone. Subsequently, histopathologic examination is used to determine type of cell death and the microscopic ablation zone. The investigators hypothesize that IRE is a safe effective method to treat colorectal liver metastasis and that cell damage and cell death is demonstrated as soon as 1 hour after the procedure.

DISEASE(S): Neoplasm Metastasis,Metastatic Liver Disease,Liver Neoplasms,Liver Diseases,Colorectal Liver Metastases

PROVIDER: 2140639 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Efficacy of Irreversible Electroporation (IRE) for Central Colorectal Liver Metastases

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