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Study of Tivantinib (ARQ 197) Plus Cetuximab in EGFR Inhibitor-Resistant MET High Subjects

ABSTRACT: This is a single-arm, Simon 2-stage, phase 2 clinical study conducted in subjects with advanced or metastatic colorectal cancer who have previously received ≥ 1 prior line of systemic therapies and are resistant to EGFR inhibitor (cetuximab or panitumumab). This trial will be conducted to determine objective response rate (ORR), progression-free survival (PFS) and overall-survival (OS) of cetuximab plus tivantinib in patients with wild-type KRAS CRC that is resistant to anti-EGFR antibody treatment (cetuximab or panitumumab) and shows overexpression of cMET.

DISEASE(S): Popolazione Pazienti Con Tumore Del Colon Retto In Fase Avanzata O Metastatica Kras Wild Type Met High In Progressione Ad Un Regime Precedente Contenente Un Inibitore Di Egfr,Malignant And Unspecified Neoplasms Gastrointestinal Nec,Colorectal Neoplasms,Colorectal Cancer Metastatic,Patients With Advanced Or Metastatic Wild Type Cras, Met High, Crc Who Have Progressed On A Previous Egfr Inibitor Based Regimen,C-met Overexpression

PROVIDER: 2147788 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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