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Individualization of Dosage of Irinotecan in the FOLFIRI According to the Genetic Polymorphism of UGT1A1 in the First Line Treatment of Metastatic Colorectal Cancer

ABSTRACT: This prospective, non randomized multicenter phase II study, will determine the feasibility of individualized dose of irinotecan with the UGT1A1 polymorphism, in patients with metastatic colorectal cancer treated with FOLFIRI.

DISEASE(S): Metastatic Colorectal Cancer,First Line Metastatic Colorectal Cancer,Cancer Colorectal Métastatique Première Ligne,Colorectal Neoplasms

PROVIDER: 2153189 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4

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A phase-II study based on dose adjustment according to UGT1A1 polymorphism: is irinotecan underdosed in first-line FOLFIRI regimen for mCRC?

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