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Anti Tumor Necrosis Factor Alpha Agents and Surgical Stress Response

ABSTRACT: Background: The immunologic response to stress is regulated by the cytokines. Anti-Tumor Necrosis Factor-α agents are antibodies directed against a key cytokine in the process angiogenesis and collagen synthesis. It is not known whether they intervene with surgical stress response increasing the rate of postoperative complications. Method: Un-blinded prospective, non-interventional cohort single centre study including all the patients with Crohn’s disease and Ulcerative Colitis undergoing abdominal surgery. Immunological and endocrinological parameters will measured in blood samples taken from these patients before and after surgery. Power calculations showed that 17 patients in each arm are needed.

DISEASE(S): Inflammatory Bowel Diseases,Intestinal Diseases,Necrosis

PROVIDER: 2154083 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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