CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

ABSTRACT: This phase I trial studies the side effects and best dose of CPI-613 (6,8-bis[benzylthio]octanoic acid) when given together with bendamustine hydrochloride and rituximab in treating patients with B-cell non-Hodgkin lymphoma that has come back or has not responded to treatment. Drugs used in chemotherapy, such as 6,8-bis(benzylthio)octanoic acid and bendamustine hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as rituximab, may find cancer cells and help kill them. Giving 6,8-bis(benzylthio)octanoic acid with bendamustine hydrochloride and rituximab may kill more cancer cells.

DISEASE(S): Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Recurrent Grade 3 Follicular Lymphoma,Recurrent Adult Acute Lymphoblastic Leukemia,Lymphoma, Large B-cell, Diffuse,Lymphoma, Large-cell, Immunoblastic,Leukemia,Mycoses,Waldenström Macroglobulinemia,Recurrent Adult Lymphoblastic Lymphoma,Small Intestine Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Refractory Hairy Cell Leukemia,Sezary Syndrome,Testicular Lymphoma,Splenic Marginal Zone Lymphoma,Leukemia, Hairy Cell,Refractory Chronic Lymphocytic Leukemia,Mycosis Fungoides,Lymphoma, Mantle-cell,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Adult Burkitt Lymphoma,Lymphomatoid Granulomatosis,Leukemia, Lymphoid,Plasmablastic Lymphoma,Precursor Cell Lymphoblastic Leukemia-lymphoma,Lymphoma, B-cell, Marginal Zone,Burkitt Lymphoma,B-cell Chronic Lymphocytic Leukemia,Lymphoma,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Recurrent Mycosis Fungoides/sezary Syndrome,Nodal Marginal Zone B-cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Marginal Zone Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,B-cell Adult Acute Lymphoblastic Leukemia,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Lymphoma, B-cell,Intraocular Lymphoma,Leukemia, Lymphocytic, Chronic, B-cell,Cutaneous B-cell Non-hodgkin Lymphoma,Recurrent Mantle Cell Lymphoma

PROVIDER: 2168930 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR