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A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b

ABSTRACT: DS-6051b is an orally administered inhibitor of the tyrosine kinases (ROS1) and neurotropic tyrosine kinase receptors (NTRK). This phase 1 first-in-human study evaluates safety and tolerability of DS-6051b in cancer subjects and identify a recommended phase 2 dose (RP2D). In addition, this study will also assess the pharmacokinetic (PK)/pharmacodynamic (PD) profiles and preliminary efficacy of DS-6051b.

DISEASE(S): Colorectal Neoplasms,Pancreatic Neoplasms,Lung Neoplasms,Neoplasms,Solid Tumors

PROVIDER: 2177400 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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