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Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

ABSTRACT: This phase I trial studies the side effects and best dose of ziv-aflibercept when given together with pembrolizumab in treating patients with solid tumors that that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Ziv-afibercept works by decreasing blood and nutrient supply to the tumor, which may result in shrinking the tumor. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving ziv-aflibercept together with pembrolizumab may be a better treatment for patients with advanced solid tumors.

DISEASE(S): Stage Iv Colorectal Cancer Ajcc V8,Metastatic Malignant Solid Neoplasm,Carcinoma,Sarcoma,Metastatic Ovarian Carcinoma,Metastatic Colorectal Carcinoma,Refractory Renal Cell Carcinoma,Melanoma,Metastatic Melanoma,Clinical Stage Iv Cutaneous Melanoma Ajcc V8,Refractory Melanoma,Metastatic Renal Cell Carcinoma,Stage Iv Renal Cell Cancer Ajcc V8,Stage Iv Ovarian Cancer Ajcc V8,Carcinoma, Ovarian Epithelial,Carcinoma, Renal Cell,Colorectal Neoplasms,Platinum-resistant Ovarian Carcinoma,Ovarian Neoplasms,Recurrent Melanoma,Recurrent Renal Cell Carcinoma

PROVIDER: 2178898 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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