C-Met Inhibitor AMG 337, Oxaliplatin, Leucovorin Calcium, and Fluorouracil in Treating Patients With Advanced Stomach or Esophageal Cancer

ABSTRACT: This partially randomized phase I/II trial studies the side effects and best dose of c-Met inhibitor AMG 337 when given together with oxaliplatin, leucovorin calcium, and fluorouracil and to see how well they work in treating patients with stomach or esophageal cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment. C-Met inhibitor AMG 337 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as, oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving c-Met inhibitor AMG 337 with oxaliplatin, leucovorin calcium, and fluorouracil may kill more tumor cells.

DISEASE(S): Adenocarcinoma,Gastrointestinal Neoplasms,Adenocarcinoma Of The Esophagus,Stage Iiic Esophageal Cancer,Stage Iv Gastric Cancer,Gastrointestinal Cancer,Adenocarcinoma Of The Gastroesophageal Junction,Stage Iiib Gastric Cancer,Stage Iiib Esophageal Cancer,Diffuse Adenocarcinoma Of The Stomach,Stage Iiia Esophageal Cancer,Esophageal Neoplasms,Intestinal Adenocarcinoma Of The Stomach,Stage Iv Esophageal Cancer,Stage Iiic Gastric Cancer,Stomach Neoplasms,Mixed Adenocarcinoma Of The Stomach,Stage Iiia Gastric Cancer

PROVIDER: 2182409 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR