Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Performance of NER1008 Enema Compared With Fleet Enema in Bowel Cleansing

ABSTRACT: In order for flexible sigmoidoscopy to be a successful screening procedure, the bowel must be free of solid matter so the endoscopist has a clear view, increasing the chance of detection of abnormalities. This is achieved through the use of bowel cleansing preparations, which are administered prior to the procedure. Enemas are the preferred method as they clear the lower bowel more quickly than oral formulations and do not require dietary restrictions. The medical device being tested in this clinical investigation is NER1008, an enema which contains PEG3350 (polyethylene glycol 3350). PEG3350 is an osmotic agent, which holds the water content in the rectum and sigmoid colon, consequently increasing stool volume, resulting in rectal distension and subsequent distal colon emptying. The increased colonic luminal content stimulates the motility, propulsive transportation and rectal evacuation of the distal colon content. This study is designed to assess the performance of NER1008 in bowel cleansing and compare this with the performance of Fleet enema, which is widely used for this purpose.

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2191902 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Bowel Preparation Impact on the Intestinal Microbiome: Oral Preparation vs Enema

Project description:Mechanical bowel preparation for left-sided colorectal surgery remains standard in most cases. However, there are some discrepancies on how to prepare the bowl, while rectal enema and oral agents are both available methods. The knowledge of intestinal microbiome role on surgical outcomes is increasing, since few recent reports linked microbiome composition to postoperative complications, such as anastomotic insufficiency. Although, it is not clear how the bowel preparation affects the gut microbiome. Therefore, different bowel preparation techniques impact on gut microbiome will be studied.

| 2310459 | ecrin-mdr-crc

Purified intestinal epithelial cells from foetal and paediatric gut

Project description:CD326+ sorted intestinal epithelial cells from foetal (9-12 wk gestational age) small bowel and large bowel, CD326+ sorted intestinal epithelial cells from mucosal biopsies of paediatric (5-15 years of age) terminal illeum, ascending colon and sigmoid colon FPG=Foetal proximal gut, FDG=Foetal distal gut, PTI=paediatric terminal ileum, PAC=paedaitric ascending colon, PSC=paediatric sigmoid colon

2015-09-15 | E-MTAB-3704 | biostudies-arrayexpress

Purified intestinal epithelial cells from foetal and paediatric gut

2015-09-15 | E-MTAB-3703 | biostudies-arrayexpress

FYO-Rat colonocytes C vs TNBS

Project description:Rats were randomly assigned to one of two different groups, a control (C, n=6) group that received a saline enema and a TNBS group (n=6) that received the TNBS challenge. Colonic epithelial cells were isolated from the distal colon of control and TNBS (non necrosed) rats by calcium chelation and percoll purification. Two mRNA samples were obtained from isolated control and TNBS rat colonocytes (pooled from n=6) further characterized with microarrays.

2018-09-10 | E-MTAB-3100 | biostudies-arrayexpress

Comparison of Mechanical Bowel Preparation Versus Enema for Candidates to Colorectal Resection for Adenocarcinoma

Project description:The purpose of this study is to evaluate mechanical bowel preparation (MBP) with polyethylene glycol plus bowel enema versus bowel enema alone in patients candidates to colorectal resection for malignancy.

| 2075204 | ecrin-mdr-crc

Characteristic Transcriptional Profiling of Rhythmic mRNA Expression in the Murine Distal Colon

Project description:To identify a cohort of rhythmically expressed genes in the murine Distal Colon,microarrays were used to measure gene expression over a 24-hour light/dark cycle.The rhythmic transcripts were classified according to expression patterns, functions and association with physiological and pathophysiological processes of the colon including motility, colorectal cancer formation and inflammatory bowel disease. Keywords: time series

2008-09-15 | GSE10644 | GEO

MiRNA expression data of distal colon mucosa from young and old mice

Project description:The disruption of the mucosal barrier of the digestive tract is a common pathological change in the elderly, which often causes inflammatory bowel disease among old people.Given that microRNA (miRNA) molecules are dysregulated in many diseases, the miRNA expression in young and old normal distal colon mucosa in mice was determined by high-throughput analysis. Three 2-month-old mice and 3 24-month-old were enrolled in this study. We used sequencing analysis to identify miRNA expression in the distal colon mucosa.

2021-05-26 | GSE175493 | GEO

Expression data from distal colon tissues of WT and Gm31629-/- mice

Project description:Mucosal healing is a key treatment goal for inflammatory bowel disease, and epithelial regeneration is required for an intact gut epithelium. Long noncoding RNAs are involved in the development of inflammatory bowel disease. Here, we investigated the role of a novel long noncoding RNA, Gm31629, in epithelial regeneration. We used RNA-seq to to detail the global programme of gene expression in distal colon tissues from WT and Gm31629-/-.

2021-12-31 | GSE168612 | GEO

MiRNA expression data of distal colon mucosa from young and old human

Project description:The disruption of the mucosal barrier of the digestive tract is a common pathological change in the elderly, which often causes inflammatory bowel disease among old people.Given that microRNA (miRNA) molecules are dysregulated in many diseases, the miRNA expression in young and old normal distal colon mucosa in humans was determined by high-throughput analysis. Three young people (27, 28, and 36 years of age) and 3 aged people (72, 79, and 81 years of age) were enrolled in this study. We used microarray analysis to identify miRNA expression in the distal colon mucosa.

2021-05-26 | GSE174837 | GEO

Project description:Bowel Preparation for Left Side Colon Surgery Impact on the Intestinal Microbiome: Oral Preparation vs Enema

| PRJNA1092444 | ENA