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Minimally Invasive Sphincter Sparing Total Mesorectal Excision for Ultra-low Rectal Cancer After Initial Chemo-radiotherapy (MISS-TRICR).

ABSTRACT: A prospective study is planned for management of low rectal cancer with the aim of sphincter preservation and improving the oncological outcome of the patients, through comparing of both approaches minimally invasive techniques including transanal total mesorectal excision and laparoscopic intersphincteric resection.

DISEASE(S): Rectal Neoplasms,Rectal Cancer

PROVIDER: 2193434 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Neoadjuvant therapy followed by local excision and two-stage total mesorectal excision: a new strategy for sphincter preservation in locally advanced ultra-low rectal cancer.

Project description:BackgroundWith the increased usage of neoadjuvant chemoradiotherapy, improved surgical technique and stapling devices, sphincter-preserving resection has become more frequent for patients with rectal cancer. However, as for locally advanced ultra-low rectal cancer, sphincter-preservation is still facing an enormous challenge.ObjectiveTo introduce an NLT strategy of sphincter-preservation-neoadjuvant therapy (NT) followed by local excision (LE) and two-stage total mesorectal excision (TME)-into the treatment of locally advanced ultra-low rectal cancer (lesions with anal sphincter invasion).MethodsFrom October 2010 to October 2011, nine patients with locally advanced rectal cancer located less than 3 cm from the anal verge were treated by the NLT strategy. All patients had shown good clinical response to NT. The LE procedure was carried transanally 6-8 weeks after completion of the NT. TME was performed to dissect mesorectal lymph nodes 4-6 weeks after LE.ResultsOf the nine patients, the lesion was assessed as T2 in two, T3 in five, and T4 in two before NT, and lymph node metastasis was detected in five patients. The median distance from the tumor to the anal verge was 2.5 cm (range: 1-3 cm). The median follow-up was 27 months (range: 24-34 months). No distant metastasis was detected. Only one patient (11.1%) developed local recurrence at 12 months post-operatively and then underwent abdomino-perineal resection. The remaining eight patients had preserved long-term continence and the median Wexner score at two years post-operation was 4 (range: 2-6).ConclusionThe new NLT strategy can achieve sphincter-preservation in some patients with ultra-low rectal cancer, with favorable oncological outcome and preservation of normal anal sphincter function.

| S-EPMC3920994 | biostudies-literature

ChIP-seq from gastroesophageal sphincter (ENCSR372QOY)

Project description:ChIP-seq on human gastroesophageal sphincter For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2017-10-23 | GSE105593 | GEO

ChIP-seq from gastroesophageal sphincter (ENCSR483GTS)

2017-10-23 | GSE105701 | GEO

ChIP-seq from gastroesophageal sphincter (ENCSR186NVR)

Project description:CTCF ChIP-seq on human gastroesophageal sphincter For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2017-10-20 | GSE105372 | GEO

ChIP-seq from gastroesophageal sphincter (ENCSR661XNQ)

2017-10-23 | GSE105609 | GEO

ChIP-seq from gastroesophageal sphincter (ENCSR414TPL)

Project description:POLR2A ChIP-seq on human gastroesophageal sphincter For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2017-10-23 | GSE105483 | GEO

ChIP-seq from gastroesophageal sphincter (ENCSR091CSG)

2017-10-20 | GSE105245 | GEO

Uptake of Total Mesorectal Excision and Total Mesorectal Excision Grading for Rectal Cancer: A Statewide Study.

Project description: Not available

| S-EPMC6895431 | biostudies-literature

The Evaluation of the Safety and the Efficacy of Transanal Total Mesorectal Excision

Project description:The purpose of this study is evaluation of the safety and the efficacy of transanal total mesorectal excision.

| 2151261 | ecrin-mdr-crc

Initial experience of abdominal total mesorectal excision for rectal cancer using the da Vinci single port system.

Project description:From November 2021 to February 2022, 15 patients underwent total abdominal mesorectal excision for rectal cancer using the da Vinci single port system. The clinical and pathological results were analyzed retrospectively. All surgeries were performed without conversion. The mean distance from the tumor to the anal verge was 10 cm (range, 2-15 cm). The mean operative time was 191 minutes, the median docking time was 4 minutes (range, 2-10 minutes), and the estimated blood loss was 20 mL (range, 20-50 mL). The mean number of lymph nodes harvested was 16.5, the mean distal resection margin was 3.52 cm, and all patients had circumferential and distal tumor-free resection margins. One patient had minor anastomotic leakage. The mean length of hospital stay was 5.8 ± 2.5 days. Abdominal total mesorectal excision using the da Vinci single port system for rectal cancer is technically feasible and safe, with acceptable pathological and short-term clinical outcomes.

| S-EPMC10728682 | biostudies-literature

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