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Outcomes of Disposable Distal Attachment Device (Endocuff and Transparent Plastic Cap) Assisted Colonoscopy

ABSTRACT: The purpose of the study is to compare the efficacy of device assisted colonoscopy (DAC) with standard colonoscopy (SC) in detecting adenomas in a randomized fashion.

DISEASE(S): Colorectal Neoplasms

PROVIDER: 2194636 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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The effect of a novel distal attachment device-assisted colonoscopy on adenoma detection rate

Project description:Interventions: Treatment group:Embrella-assisted colonoscopy;Control group:Standard colonoscopy Primary outcome(s): Adenoma detection rate(ADR) Study Design: Parallel

| 87667 | ecrin-mdr-crc

Comparison of colon adenoma detection rates using cap-assisted and Endocuff-assisted colonoscopy: a randomized controlled trial.

Project description:Objectives and study aim Colonoscopy prevents colorectal cancer by removing adenomatous polyps, but missed adenomas lead to interval cancers. Different devices have been used to increase adenoma detection rates (ADR). Two such devices of interest are the transparent cap (Olympus) and Endocuff (ARC Medical). Our study aimed to compare differences in ADR between Endocuff-assisted colonoscopy (EAC), cap-assisted colonoscopy (CAC) and standard colonoscopy (SC). Patients and methods A sample size of 126 subjects was calculated to determine an effect size of 30 %. Patients undergoing screening or surveillance colonoscopy between March 2016 and January 2017 were randomized to SC, CAC or EAC groups. Three experienced endoscopists performed all colonoscopies. Patient demographics, procedure indication, Boston Bowel Prep Score (BBPS), withdrawal time, polyp size, location, histopathology, were analyzed. Results There was no difference in ADR (52 %, 40 % and 54 %) in the SC, CAC and EAC groups respectively ( P = 0.4). Similar findings were also observed for proximal ADR (45 %, 35 %, and 50 %, P = 0.4) and SSA detection rate (16 %, 14 %, and 23 %, P = 0.5). EAC detected higher mean ADR per colonoscopy compared to CAC (1.70 vs 0.76, P = 0.01). However, there was no significant difference in mean ADR per positive colonoscopy (2.08, 1.63, and 2.59, P = 0.21). Conclusion In a randomized controlled trial comparing AC to CAC and SC, neither device conferred additional benefits in ADR among high detectors. When comparing each device, EAC may be better than CAC at detecting more total adenomas.

| S-EPMC6877415 | biostudies-literature

Standard versus Endocuff versus cap-assisted colonoscopy for adenoma detection: A randomised controlled clinical trial.

Project description:Background and aimsAdenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy (SC) with Endocuff-assisted colonoscopy (EC) and cap-assisted colonoscopy (CAC) for improvement of ADR.MethodsPatients from Poland and Germany with independent indication for colonoscopy were randomised into three arms of this trial: EC, CAC and SC. Exclusion criteria were age <18 years, active Crohn's disease or ulcerative colitis, known stenosis and post-colonic resection status.ResultsA total of 585 patients (195 SC, 189 EC and 186 CAC) were enrolled in this study. Indications were not different between the groups (colorectal cancer screening 51%, diagnostic colonoscopy in 31% and post-polypectomy follow-up in 18%; p = 0.94). Withdrawal time was a mean of 7 min in all groups (p = 0.658), and bowel preparation did not differ between the groups. The time to reach the caecum was significantly reduced when using the cap (a mean of 6 min for CAC vs. 7 min for SC; p = 0.0001). There was no significant difference in the primary outcome of the ADR between the groups (EC 32%, CAC 30%, SC 30%; p = 0.815). EC proved to be superior (EC vs. SC) in the sigmoid colon and transverse colon for polyp detection.ConclusionThe use of EC increased the total number of polyps seen during colonoscopy. In contrast to recent studies, no significant improvement of the ADR was detected.

| S-EPMC8259258 | biostudies-literature

Serrated Lesions Detection With Endocuff-assisted Colonoscopy

Project description:Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide, especially in Western countries. CRC is currently considered a preventable disease and screening has been endorsed by several societies, since it has been shown that screening and surveillance are effective in reducing both CRC incidence and mortality. However, recently, concern has risen regarding colonoscopy effectiveness, especially in the right colon. The most accepted explanation for this effectiveness variability is attributed to sessile serrated lesions (SSL), which are more frequent in the proximal colon, more difficult to detect because of their flat morphology and associated with interval CRC, which is the occurrence of CRC after screening colonoscopy and before the next scheduled procedure. Several techniques are emerging to increase the sensitivity of colonoscopy for pre-cancerous lesions, especially adenomas. Recently an endoscopic cap, the Endocuff, was developed to improve adenoma detection. Several studies demonstrated improved adenoma detection with Endocuff-assisted colonoscopy when compared with conventional colonoscopy. Still, the available data for its’ role in detecting SSL is very limited. The aim of this randomized controlled trial is to evaluate the effectiveness of Endocuff-assisted colonoscopy in detection of colorectal SSL.

| 2298416 | ecrin-mdr-crc

Comparison of computer-aided diagnosis colonoscopy, Endocuff-Assisted Colonoscopy, combination of computer-aided diagnosis colonoscopy and Endocuff-Assisted Colonoscopy and High-definition Colonoscopy for Adenomas Detection in Colorectal Cancer Screening

Project description:Interventions: CAD EYE detection and characterization and Endocuff-assisted colonoscopy (CAD EYE + EAC),CAD EYE detection and characterization,Endocuff-assisted colonoscopy (EAC),Standard colonoscopy;Experimental Device,Experimental Device,Experimental Device,Active Comparator Device;CAD EYE detection and characterization and Endocuff-assisted colonoscopy (CAD EYE + EAC),CAD EYE detection and characterization,Endocuff-assisted colonoscopy (EAC),Standard colonoscopy Primary outcome(s): Adenoma detection rate After colonoscopy Histopathology Study Design: Randomized

| 2569421 | ecrin-mdr-crc

Comparison of Linked Color Imaging, Endocuff-Assisted Colonoscopy, combination between Linked Color Imaging and Endocuff-Assisted Colonoscopy and High-definition Colonoscopy for Adenomas Detection in Colorectal Cancer Screening: A Randomized Trial

Project description:Interventions: Linked color imaging (LCI),Endocuff-assisted colonoscopy (EAC),Linked color imaging and Endocuff-assisted colonoscopy (LCI+EAC),Standard white light high-definition colonoscopy;Experimental Device,Experimental Device,Experimental Device,Placebo Comparator Device;Linked color imaging (LCI),Endocuff-assisted colonoscopy (EAC),Linked color imaging and Endocuff-assisted colonoscopy (LCI+EAC),Standard white light high-definition colonoscopy Primary outcome(s): Adenoma detection rate in each group Crossectional study Adenoma from colonoscopies Study Design: Randomized

| 2567682 | ecrin-mdr-crc

Effect of an Artificial Intelligence Computer-Aided Detection System on Adenoma Detection: A Multicenter Randomized Controlled Trial

Project description:Interventions: SC-AI group:standard colonoscopy is performed first, followed by AI-assisted colonoscopy;AI-SC group:AI-assisted colonoscopy is performed first, followed by standard colonoscopy Primary outcome(s): adenoma miss rate Study Design: Cross-over

| 80559 | ecrin-mdr-crc

Endocuff for Surveillance of Serrated Polyposis Syndrome

Project description:Serrated Polyposis Syndrome (SPS) is a high-risk condition for colorectal cancer (CRC). SPS patients have a cumulative CRC risk of 1.9% in 5 years despite a strict endoscopic surveillance in specialized centers. Proximal serrated lesions are endoscopically challenging to detect due to their unremarkable morphology. Endocuff is a novel device comprised of a cap with a row of finger-like projections with a unique dynamic shape that help to flatten mucosal folds during withdrawal of the instrument in order to improve detection of lesions. Recent studies have reported an increase of detection rate and mean per patient of adenomas with Endocuff-assisted Colonoscopy compared with Standard Colonoscopy. The purpose of this study is to assess the usefulness of Endocuff-assisted Colonoscopy to detect serrated lesions in SPS patients undergoing surveillance compared to Standard Colonoscopy in a randomized fashion

| 2201392 | ecrin-mdr-crc

Bose2011 - Noise-assisted interactions of tumor and immune cells

Project description:Noise-assisted interactions of tumor and immune cells. Bose T1, Trimper S. Author information 1 Institute of Physics, Martin-Luther-University, D-06099 Halle, Germany. thomas.bose@physik.uni-halle.de Abstract We consider a three-state model comprising tumor cells, effector cells, and tumor-detecting cells under the influence of noises. It is demonstrated that inevitable stochastic forces existing in all three cell species are able to suppress tumor cell growth completely. Whereas the deterministic model does not reveal a stable tumor-free state, the auto-correlated noise combined with cross-correlation functions can either lead to tumor-dormant states, tumor progression, as well as to an elimination of tumor cells. The auto-correlation function exhibits a finite correlation time τ, while the cross-correlation functions shows a white-noise behavior. The evolution of each of the three kinds of cells leads to a multiplicative noise coupling. The model is investigated by means of a multivariate Fokker-Planck equation for small τ. The different behavior of the system is, above all, determined by the variation of the correlation time and the strength of the cross-correlation between tumor and tumor-detecting cells. The theoretical model is based on a biological background discussed in detail, and the results are tested using realistic parameters from experimental observations.

2024-09-02 | BIOMD0000000894 | BioModels

A prospective, multicenter, randomized control trial of a real-time quality-control system for the colonoscopy examination of outpatient

Project description:Interventions: AI-first group:AI-assisted colonoscopy is performed first, followed by standard colonoscopy;SC-first group:standard colonoscopy is performed first, followed by AI-assisted colonoscopy Primary outcome(s): adenoma miss rate Study Design: Cross-over

| 47631 | ecrin-mdr-crc

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