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A Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 and Selumetinib in Combination With MEDI4736 and Tremelimumab in Patients With Advanced Solid Tumours

ABSTRACT: This is a Phase I, open-label, multi-centre, drug combination study of double and triple combination oral selumetinib (AZD6244 Hyd-sulfate) plus intravenous (IV) MEDI4736 and oral selumetinib plus IV MEDI4736 and IV tremelimumab in patients with advanced solid tumours.

DISEASE(S): Head And Neck Carcinoma,Lung Cancer,Pancreatic Adenocarcinoma,Biliary Tract Cancer,Biliary Tract Neoplasms,Melanoma,Colorectal Cancer,Gastroesophageal Cancer,Breast Cancer

PROVIDER: 2200961 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Gene expression profiling during treatment of HT29 cells with selumetinib

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A Phase 1 Study to Evaluate MEDI4736 in Combination With Tremelimumab

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First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial [scRNA-Seq]

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