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Phase II Study of Perindopril and Regorafenib in mCRC

ABSTRACT: The purpose of this study is to find out what effects the combination of regorafenib and perindopril has on hand-foot skin reaction (HFSR), on high blood pressure (hypertension) and on any other types of side-effects and compare it to the published incidence of the side-effects with regorafenib alone. This research is being done in an attempt to reduce the side-effects associated with regorafenib.

DISEASE(S): Metastatic Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2205892 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Dexamethasone induced gene expression changes in the human trabecular meshwork

Project description:One of the undesirable side effects of glucocorticoid use is the potential development of elevated intraocular pressure and glaucoma. The precise mechanisms through which steroid use induces ocular hypertension are unclear. The purpose of this study was to identify gene expression changes induced by steroids in the human trabecular meshwork and the underlying sclerocorneal tissue.

2012-10-01 | GSE37474 | GEO

MicroRNA of exosome in Hand, foot and mouth disease serum samples

Project description:The some biomarkers can be found by pairwise comparison. They can distinguish between extremely severe Hand,foot and mouth disease and mild Hand,foot and mouth disease,moreover,they can applied to diagnose extremely severe Hand,foot and mouth disease mild Hand,foot and mouth disease vs.control; extremely severe Hand,foot and mouth disease vs.control; extremely severe Hand,foot and mouth disease vs.mild Hand,foot and mouth disease,verification by qRT-PCR

2013-11-27 | E-GEOD-52780 | biostudies-arrayexpress

Dexamethasone induced gene expression changes in the human trabecular meshwork

2012-10-01 | E-GEOD-37474 | biostudies-arrayexpress

MicroRNA of exosome in Hand, foot and mouth disease serum samples

2013-11-27 | GSE52780 | GEO

Proteomics of Human Hepatoma Huh-7 Cells Treated by Three Multi-RTK Inhibitors

Project description:Sorafenib, lenvatinib and regorafenib, the multi-RTK inhibitors with potent anti-angiogenesis effects, are currently therapeutic drugs generally recommended for the patients with advanced hepatocellular carcinoma (HCC). To date, however, there have been no published studies on the mechanism underling differential effects of the three drugs on HCC cell proliferation, and the proteomic analysis in HCC cell lines treated by regorafenib or lenvatinib.The present project for the first time performed a direct comparison of their pharmacological interventions for influencing whole cell proteomics using tandem mass tag-based peptide-labeling technique.

2022-10-13 | PXD034073 | Pride

Randomized Controlled Study of Preventive Effect of TDX105 on Regorafenib Induced Dermatologic Toxicities

Project description:Interventions: Experimental group:Fufang Danxiong Granules (TDX105);Control group:Placebo Primary outcome(s): Incidence of grade 3 hand and foot skin reaction Study Design: Cross-sectional

| 37419 | ecrin-mdr-crc

Stump project-- miRNA whole tissue; Volar versus non-volar acral skin gene expression

Project description:To broaden our understanding of the gene expression common to volar skin, we biopsied the dorsum of the hand, palm, dorsum of the foot and sole and collected miRNA for chip anlayses total of 16 skin biopsy samples with 4 repeats from distinct individuals of each site: dorsum of hand, palm, dorstum of foot and sole

2013-07-03 | E-GEOD-38732 | biostudies-arrayexpress

Comprehensive transcriptome analysis of lung tissues in the sugen/hypoxia rats with/without treatment of chrysin or trimetazidine

Project description:Pulmonary arterial hypertension (PAH) is a debilitating progressive disease characterized by high blood pressure in the pulmonary artery. Chrysin (5,7-dihydroxyflavone) is a phytochemical, which is a flavonoid widely present in plant sources. It is known that right ventricular dysfunction is the worst mortality predictor in patient with PAH. Recent studies have shown that chrysin improves hemodynamic parameters including right ventricular pressure, right ventricular hypertrophy, and pulmonary vascular remodeling in a rat model of chronic hypoxia-induced pulmonary hypertension. On the other hand, trimetazidine (TMZ) is an anti-ischemic agent widely used in the treatment of coronary artery disease. It has been reported that trimetazidine therapy for 3 months on top of standard PAH regime significantly improve right ventricular ejection fraction and functional capacity in patient with PAH. However, the effects of chrysin or trimetazidine on gene expression in lung of patient with PAH. Here, we performed that a comprehensive analysis of gene expression changes in lung tissues of sugen-received rats under hypoxic conditions, which is a model of PAH with chrysin or trimetazidine treatment using RNA sequencing (RNA-seq).

2024-05-16 | GSE186996 | GEO

Stump project -- methylation whole tissue; volar versus non-volar acral skin gene expression

Project description:To broaden our understanding of the gene expression common to volar skin, we biopsied the dorsum of the hand, palm, dorsum of the foot and sole and collected DNA for methylation chip anlayses Total of 12 skin biopsy samples with 3 repeats from distinct individuals of each site: dorsum of hand, palm, dorstum of foot and sole. The samples below represent methylation data only.

2013-07-03 | E-GEOD-39131 | biostudies-arrayexpress

Changes of Granulation Tissue Protein Mass Spectrometry in Foot Wound of Diabetes Mellitus after Negative Pressure wound therapy

Project description:Before and after negative pressure treatment in 3 diabetic foot patients, the granulation tissue of foot ulcer was sampled and analyzed quantitatively by LC-MS /MS method.

2020-08-17 | PXD020929 |

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