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Safety and Effect of GL-ONC1 Administered IV Prior to Surgery to Patients With Solid Organ Cancers Undergoing Surgery

ABSTRACT: The purpose of this study is to evaluate the safety of the investigational product GL-ONC1. GL-ONC1, a vaccinia virus, has been genetically modified for use as a potential anti-cancer drug to destroy cancer cells. Vaccinia virus has been used successfully in the past as smallpox vaccine in millions of people worldwide.

DISEASE(S): Solid Organ Cancers,Mesothelioma,Cancer

PROVIDER: 2210711 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection

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Effect of human DAI expressed by an oncolytic vaccinia virus on the gene expression of tumor cells (HS294T) and monocytes (THP-1).

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