A Study of Combinations of D-CIK Immunotherapy And Anti-PD-1 In Refractory Solid Tumors
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ABSTRACT: Background: Combinations of dendritic and cytokine-induced killer cell (D-CIK) based adoptive immunotherapy and anti-PD-1 antibody may enhance the immune response and stop cancer cells from growing.
Objective: Phase II clinical trial to investigate the safety, clinical activity and toxicity of combinations of D-CIK and anti-PD-1 antibody in patients with treatment-refractory solid tumors.
Methodology: Phase II clinical trial in patients with advanced metastatic hepatocellular carcinoma, renal cell carcinoma,bladder cancer,colorectal cancer,non-small-cell lung cancer,breast cancer and other solid cancers. The D-CIK was isolated from peripheral blood of participants,then activated,expanded and incubated with anti-PD-1 antibody before infusion. The enough number (1.0-1.5 *10^10 cells) of D-CIK were infused back into participants.
DISEASE(S): Carcinoma,Colorectal Cancer,Carcinoma, Renal Cell,Bladder Cancer,Non-small-cell Lung Cancer,Renal Cell Carcinoma,Breast Cancer,Hepatocellular Carcinoma
PROVIDER: 2223938 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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