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Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer

ABSTRACT: This randomized phase II trial studies the side effects of durvalumab and tremelimumab and to see how well they work with or without high or low-dose radiation therapy in treating patients with colorectal or non-small cell lung cancer that has spread to other parts of the body (metastatic). Immunotherapy with durvalumab and tremelimumab, may induce changes in body’s immune system and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving durvalumab and tremelimumab with radiation therapy may work better in treating patients with colorectal or non-small cell lung cancer.

DISEASE(S): Stage Iva Colorectal Cancer Ajcc V7,Stage Iv Colorectal Cancer Ajcc V7,Stage Iv Lung Non-small Cell Cancer Ajcc V7,Stage Ivb Colorectal Cancer Ajcc V7,Carcinoma,Metastatic Colorectal Carcinoma,Colorectal Neoplasms,Carcinoma, Non-small-cell Lung,Metastatic Lung Non-small Cell Carcinoma

PROVIDER: 2224080 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial [scRNA-Seq]

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