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Comparison of Detection and Miss Rates of Blue Laser Imaging Versus Conventional White Light Colonoscopy

ABSTRACT: It is a randomized controlled trial with tandem colonoscopy.Participants were randomized for use of either blue laser imaging or conventional White Light Colonoscopy on withdrawal method.comparison of detection and miss rates of BLI group Versus conventional White Light Colonoscopy.

DISEASE(S): Colorectal Adenoma,Adenoma

PROVIDER: 2231269 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Gene expression data from retina of Babl/c mouse under white LED light exposure

Project description:The widely used white light-emitting diodes (LED) deliver higher levels of blue light than do conventional domestic light sources. The high intensity of blue component is the main source of concern about the health risks of LED with respect to their light-toxicity to the retina. White LED light with higher correlated color temperature (CCT) is more likely to cause retinal injury in mice, significantly reducing the number of ONL nuclei, however apoptosis pathway may not be the only mechanism. We used the Affymetrix GeneChip (Mouse Genome 430 2.0) to describe the different influence on gene expression of mouse retina under white LED light with different CCT.

2017-11-28 | GSE107382 | GEO

I-Scan Versus High-definition White Light

Project description:The purpose of the study is to assess whether the use of I-scan during colonoscopy leads to an increased yield of adenomas in the colon among a population at increased risk for CRC. Primary Outcome: To estimate the mean number of adenomas per colonoscopy for both high definition white light colonoscopy and I-scan enhanced colonoscopy Secondary Outcomes: 1. To estimate the recruitment rate 2. Number of adenomas detected in the right colon during the second look

| 2126787 | ecrin-mdr-crc

Blue light inhibition of tuberization

Project description:A tuberization inhibitor has long been postulated, but not yet found. We found that blue light inhibits tuberization in Norland, a day-neutral variety of Solanum tuberosum L. Tissue-cultured plants formed tubers within 8 weeks under continuous darkness, and white, red, or far-red light. Preliminary experiments indicated that a one- or two-day exposure to blue light after 3-4 weeks of dark treatment will inhibit tuber formation in ‘Norland’ plants. Using this system and expression profiling, we may be able to identify candidate tuberization inhibitors. 'Norland' plants (subcultured from existing cultures and grown for two weeks under continuous 100 umol/m2-s white fluorescent light) were placed in tuber-inducing media containing 6% sucrose, vitamins, MS salts, and kinetin (2.5 mg/L). Tubes containing plants were wrapped in two layers of aluminum foil. After 3 weeks and 2 days, half of the tubes were exposed to 6-7 umol/m2-s blue light. The other half of the tubes were left in darkness (controls). After 2 days, all plants were harvested and frozen in liquid nitrogen. Plants exposed to blue light were harvested under blue light. Control plants were harvested under < 2 umol/m2-s light conditions. All plant transfers were done at 1700 (5 PM) to avoid possible complications due to circadian effects. Experiments were performed four times, from subculture to harvest. RNA was extracted from stem and leaf tissue of plants using the Qiagen RNeasy Plant Mini kit. Extracted RNA was then converted to dsDNA using the Invitrogen protocol and reagents for double stranded cDNA synthesis. The resulting dsDNA was in vitro transcribed into amplified RNA using the Ambion procedure and reagents for in vitro transcription. cDNA was purified using Qiagen MinElute columns and protocol. Amplified RNA was purified using Ambion columns or Qiagen RNeasy columns and the Ambion protocol, and quantified using RiboGreen dye fluorometry. Keywords: Direct comparison

2008-02-13 | GSE10491 | GEO

A Multi Center Study Comparing the Efficacy of CAD EYE and the Standard of Care (White Light )

Project description:This study is to assess the sensitivity and added benefits of CADEYE compared to standard care (white-light) in detecting colon polyps in patients undergoing colonoscopy.

| 2746974 | ecrin-mdr-crc

Study of Flat Polyp Detection Using New Narrow Band Imaging (NBI) Compared to White Light Colonoscopy - The FIND FLAT Colonoscopy Study

Project description:We hypothesize that high definition narrow band imaging (NBI) colonoscopy compared to high definition white light colonoscopy will detect an increased number of nonpolypoid (flat and depressed) colorectal neoplasm.

| 2103409 | ecrin-mdr-crc

I-Scan Vs High Definition White Light (Main Study)

Project description:The purpose of this study is to assess whether the use of I-Scan during colonoscopy leads to an increased yield of adenomas in the colon among a population at increased risk for CRC. Primary Outcome: Adenoma Detection Rate (ADR - No. of colonoscopies at which one or more histologically confirmed adenomas were found divided by the total no. of colonoscopies performed in the same time period) in the right colon using High Definition White Light Colonoscopy Versus I-Scan enhanced Colonoscopy. Secondary Outcomes: * Adenoma Detection Rate (ADR) of High Definition White Light Colonoscopy Versus I-Scan colonoscopy through out the entire colon. * Adenoma Detection Rate (ADR) in the right colon during the "Second look", irrespective of imaging modality. * Polyp Detection Rate (PDR - No. of colonoscopies at which one or more polyps were found(regardless of the histological type) divided by the total no. of colonoscopies performed in the Same time period) for each arm of the study in Right colon and throughout the entire colon. * Mean number of adenomas per procedure for each arm of the study in right colon and throughout the entire colon. * Mean number of polyps per procedure for each arm of the study in right colon and throughout the entire colon. * Number of neoplastic lesions for each arm of the study in the right colon and throughout the entire colon and number of neoplastic lesions missed on 1st pass of right colon. * Proportion of patients with diminutive lesions (< 5 mm) in each arm of the study * Proportion of patients with Flat lesions (height < 1/2 diameter) in each arm of the study * Proportion of patients with Sessile Serrated Adenoma in each arm of the study * Proportion of patients with invasive cancer in each arm of the study * Presence or absence of learning effect while using this technology given that use of I-Scan may train the human eye to better identify adenomas even without image enhancement.

| 2157253 | ecrin-mdr-crc

The comparison of AI-assisted colonoscopy and conventional colonoscopy for the detection of polyps in colorectal cancer screening in White Light and LCI mode

Project description:Interventions: A:white light / white light+ AI;B:LCI / LCI+AI Primary outcome(s): polyp detection rate Study Design: Parallel

| 2687693 | ecrin-mdr-crc

Narrow-band imaging versus white light for detection of diminutive colorectal adenoma using wide-view and high-definition colonoscope (HQ290ZI): A randomized controlled trial

Project description:Interventions: narrow-band imagaing white light Primary outcome(s): Comparison of narrow-band imaging versus white light imaging for diminutive adenoma detection rate Study Design: Parallel Randomized

| 2632400 | ecrin-mdr-crc

Electronic Staining increases the Detection of Tumors of the Large Intestine and Rectum

Project description:Interventions: Group 1:151 patients will be submitted to colonoscopy with use of linked color (LCI); Group 2: 150 patients will be submitted to colonoscopy with use of blue laser brght-mode (BLI-bright) and; Group 3: 150 patients will undergo colonoscopy with white light (WLI). The electronic chromoscopy technique used at each colonoscopy (in each patient) will be determined according to the randomization.;Device;E01.370.372.250.250.200 Primary outcome(s): Adenoma detection rate, evaluated by the techniques of linked color imaging (LCI), white light imaging (WLI) and blue laser imaging (BLI-bright) and confirmed by a blinded pathologist within 7 days of the colonoscopy. Study Design: clinical trial of diagnosis, randomized-controlled, parallel, open, with 3 arms

| 2562397 | ecrin-mdr-crc

Effect of a new light and contrast mechanism on the detection of lesions in Endoscopic examination of the colon in Cancer screening procedures

Project description:Interventions: 200 patients will undergo diagnostic colonoscopy, prior to the examination all patients must ingest 1 liter of 10% mannitol solution on the day of the examination, preceded by a day with a diet of clear liquids without fibers, for intestinal cleaning. Patients will be randomized to one of the following groups: (White light image-WLI, blue light-BLI-bright, and Linked color Imaging-LCI). We will compare the ability to detect lesions in the intestine between these different types of light and image in each group.;Other;E01.370.372.250.250.200 Primary outcome(s): Evaluate the percentage increase in the detection rate of colorectal adenomas using colonoscopy with Linked Color Imaging as a method Study Design: Diagnostic clinical trial, randomized-controlled, parallel, blind, with three arms

| 2561088 | ecrin-mdr-crc

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