Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A Study of SC-007 in Subjects With Advanced Cancer

ABSTRACT: This is a multicenter, open-label, Phase 1 study in participants with colorectal cancer (CRC) or gastric cancer to study the safety and tolerability of SC-007 and consists of Part A (dose regimen finding) in participants with CRC followed by Part A in participants with gastric cancer. Part B (dose expansion) will enroll participants into separate disease specific cohorts of CRC or gastric cancer.

DISEASE(S): Colorectal Cancer (crc),Gastric Cancer,Colorectal Neoplasms,Advanced Cancer,Stomach Neoplasms,Cancer

PROVIDER: 2252059 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

A Study of SC-006 and in Combination With ABBV-181 in Subjects With Advanced Colorectal Cancer

Project description:This is a multicenter, open-label, Phase 1 study of SC-006 given as a single agent and in combination with ABBV-181 in participants with advanced colorectal cancer (CRC), and consists of Part A (single agent SC-006 dose regimen finding), followed by Part B (single agent SC-006 dose expansion), and Part C (SC-006 and ABBV-181 combination escalation and expansion). Part A (dose regimen finding) will involve dose escalation and possible dose interval modification to define the maximum tolerated dose (MTD) and/or recommended Part B dose and schedule. Part B (dose expansion) will enroll additional participants who will be treated with a study drug dose at or below the MTD determined in Part A. Part C is dose escalation of SC-006 and fixed dose of ABBV-181 in combination. Recommended dose cohort of SC-006 with ABBV-181 will be expanded.

| 2235325 | ecrin-mdr-crc

E-GEOD-19826

Project description:Transcription profiling by array of human gastric cancer samples

2025-01-24 | E-GEOD-19826 | ExpressionAtlas

E-GEOD-68238

Project description:Redefining the role of eIF4E dose in development, cancer, and protein synthesis

2015-09-18 | E-GEOD-68238 | ExpressionAtlas

Dissecting the mechanism of action of spiperone, a candidate of drug repurposing for colorectal cancer

Project description:We evaluated the modulation of mRNA upon spiperone treatment in colorectal cancer epithelial cell line (HCT116) and colorectal cancer stem cells (CRC-SC#1)

2022-02-08 | GSE190093 | GEO

Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer

Project description:To understand epigenetic changes in the distal regulatory as well as proximal regions, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines MBD sequencing of normal tissue (n), purified gastric cancer (sc), and cultured gastric cancer cell (dc) were generated by deep sequencing, in five samples from three patients (csc1, csc2, csc3) and two replicates (csc1_sc2, csc1_sc3), using Illumina GAIIx.

2016-03-28 | E-GEOD-46595 | biostudies-arrayexpress

Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer

Project description:To understand epigenetic changes in the distal regulatory as well as proximal regions, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines. mRNA sequencing profiles of normal tissue (n), purified gastric cancer (sc), and cultured gastric cancer cell (dc) were generated by deep sequencing, in five samples from three patients (csc1, csc2, csc3) and two replicates (csc1_sc2, csc1_sc3), using Illumina GAIIx and HiSeq2000.

2016-03-28 | E-GEOD-46597 | biostudies-arrayexpress

E-MTAB-8135

Project description:Global gene expression profiles of 10 gastric cancer (GC) samples and 10 gastric normal adjacent tissue (gNAT) samples

2025-01-16 | E-MTAB-8135 | ExpressionAtlas

E-MTAB-4736

Project description:Transcription profiling by array of trichostatin-A treated gastric cancer cell lines

2025-01-23 | E-MTAB-4736 | ExpressionAtlas

Prediction of Golimumab Response in the PROgECT Phase 2a Open-Label Trial of Patients With Ulcerative Colitis

Project description:PROgECT (ClinicalTrials.gov Identifier: NCT01988961) was a multicenter, open-label study evaluating the accuracy of a probe-set panel in predicting response to golimumab treatment in participants with moderately to severely active ulcerative colitis (UC). Biopsy samples (collected 15 to 20 cm from the anal verge) were taken at screening from 84 patients and used for RNA extraction and profiling by microarrays. All patients enrolled in the study received the approved induction dose regimen of subcutaneous (SC) golimumab.

2022-09-08 | GSE212849 | GEO

E-GEOD-29272

Project description:Affymetrix gene expression array data for cardia and non-cardia gastric cancer samples

2025-01-24 | E-GEOD-29272 | ExpressionAtlas