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Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers

ABSTRACT: The purpose of this study is to determine the safety and tolerability, describe the dose-limiting toxicities (DLTs), and determine the maximum tolerated dose (MTD) (or the highest protocol-defined dose level in the absence of establishing an MTD) of ibrutinib in combination with pembrolizumab in participants with advanced, refractory colorectal cancers.

DISEASE(S): Colorectal Carcinoma,Colon Disease,Colon Cancer,Colorectal Cancer,Colorectal Neoplasms,Colonic Diseases

PROVIDER: 2258148 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors

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NCIC CTG MA.22 phase I/II trial of epirubicin and docetaxel in locally advanced breast cancer on 2-weekly or 3-weekly schedules

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First-in-human study of the novel fibroblast activation protein-targeted 4-1BB agonist RO7122290 in patients with advanced solid tumors

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miRNA expression profiles of erythroid cells following hydroxyurea treatment for sickle cell anemia

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miRNA expression profiles of erythroid cells following hydroxyurea treatment for sickle cell anemia

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