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Peripheral Parenteral Nutrition vs Conventional Fluid in Colorectal Resection in ERAS

ABSTRACT: Assess if administration of early nutrition support with Perioperative Peripheral Nutrition (PeriOliclimonel) N4-E) in patients undergoing colon cancer resection in an Enhanced Recovery After Surgery (ERAS) Protocol improve the results of morbi-mortality and hospitalization versus standard intravenous fluid therapy.

DISEASE(S): Fast-track,Colon Cancer,Parenteral Nutrition,Colonic Neoplasms

PROVIDER: 2279204 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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A RANDOMIZED, CONTROLLED, CLINICAL TRIAL TO COMPARE PERIPHERAL PARENTERAL NUTRITION (PeriOlimel N4-E) VS CONVENTIONAL FLUID THERAPY IN ENHANCED RECOVERY AFTER SURGERY (ERAS) PROTOCOL IN COLORECTAL CANCER SURGERY.

Project description:Primary objectives: The main objective is to determine if perioperative nutritional support with PeriOlimel N4-E, that reaches nutritional requirements of ERAS protocol for colorectal cancer surgery patients, can improve nutritional status so it decreases postoperative complications, hospital length of stay and costs, compared to conventional fluid therapy administration since patients receive oral nutrition at day 3-5. Primary endpoints: We set the primary endpoint as the presence of surgical postoperative complications during the first postoperative month.

| 2535241 | ecrin-mdr-crc

Gene Expression of MCF10A cells expresing ERAS

Project description:ERAS (Embryonic stem (ES) cell-expressed Ras) is a constitutively active member of the Ras family that is not expressed in adult tissues, and has been involved in breast cancer. ERAS was introduced in breast MCF10A cells using a lentiviral vector under the control of the beta actin promoter

2018-08-01 | GSE104859 | GEO

Altered RNA expression in parenteral nutrition mouse model

Project description:We reported altered RNA expression profiles in wild-type (WT) C57BL/6J mice upon parenteral nutrition treatment compared to saline infusion controls. RNA samples used were isolated from the livers of PN or saline infused mice. RNA samples from 3 saline or 3 PN mouse livers were pooled, respectively. Final fold change were calculated by normalize the signal intensity of each probe in PN sample to that of the saline sample.

2016-02-01 | GSE71286 | GEO

RNA-sequencing identifies novel transcriptomic signatures in parenteral nutrition-associated liver disease

Project description:RNA-sequencing in liver from control and parenteral nutrition-associated liver disease (PNALD) rats

2022-06-01 | GSE171007 | GEO

Transcriptomic analysis of early IFALD in preterm piglets receiving parenteral nutrition

Project description:Preterm Yorkshire piglets were provided parenteral nutrition for 14 days and developed cholestasis and histologic liver injury. Bottle-fed age-matched controls were provided sow milk replacer every 2-3 hours for 14 days.

2023-08-02 | GSE234108 | GEO

Transcriptomic analysis of SEFA-6179 treatment in preterm piglets receiving parenteral nutrition

Project description:Preterm Yorkshire piglets were provided parenteral nutrition for 14 days, receiving treatment with SEFA-6179 or a medium chain triglyceride vehicle control. At the end of 14 days, MCT piglets developed cholestasis and histologic liver injury.

2023-06-03 | GSE223347 | GEO

Gene Expression of MCF10A cells expresing ERAS

Project description:Gene Expression of MCF10A cells expresing ERAS

| PRJNA414043 | ENA

Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures

Project description:Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults. However, despite numerous benefits, TPN can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. IFALD pathogenesis is complex, depending on the TPN components as well as on the patient’s medical conditions. Despite numerous animal studies and clinical observations, the molecular mechanisms driving IFALD remain largely unknown. The present study was set up to elucidate the mechanisms underlying IFALD. For this purpose, human liver spheroid co-cultures were treated with TPN mixture followed by RNA sequencing analysis. It was found that prolonged exposure to TPN substantially changes the transcriptome profile of liver spheroids and affects multiple metabolic and signaling pathways contributing to liver injury.

2024-05-03 | GSE264357 | GEO

Transcriptomic analysis of early IFALD in preterm piglets receiving parenteral nutrition

Project description:Transcriptomic analysis of early IFALD in preterm piglets receiving parenteral nutrition

| PRJNA980120 | ENA

TOTAL PARENTERAL NUTRITION.

Project description:Total parenteral nutrition has been used in clinical practice for over a quarter of a century. It has revolutionized the management of potentially fatal condition like the short bowel syndrome in infants as well as adults. Refinements in techniques have led to development of sophisticated catheters and delivery systems. Better understanding of human nutrition and metabolic processes has lead to formulation of scientific parenteral solutions to suit specific situations. This article addresses the role of total parenteral nutrition in modern surgical practice.

| S-EPMC5529889 | biostudies-other

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