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A Study of XmAb23104 in Subjects With Selected Advanced Solid Tumors (DUET-3)

ABSTRACT: This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors.

DISEASE(S): Endometrial Cancer,Carcinoma,Small Cell Lung Cancer,Colorectal Cancer,Advanced Solid Tumors,Cervical Carcinoma,Urothelial Carcinoma,Endometrial Neoplasms,Breast Neoplasms,Pancreatic Carcinoma,Lung Neoplasms,Gastric Or Gastroesophageal Junction Adenocarcinoma,Colorectal Carcinoma,Melanoma (excluding Uveal Melanoma),Squamous Cell Carcinoma Of The Head And Neck,Gastric Cancer,Colorectal Neoplasms,Carcinoma, Non-small-cell Lung,Renal Cell Carcinoma,Pancreatic Neoplasms,Non-small Cell Lung Carcinoma,Hepatocellular Carcinoma,Nasopharyngeal Carcinoma,Breast Carcinoma That Is Estrogen Receptor, Progesterone Receptor, And Her2 Negative,Sarcoma,Cervical Cancer,Melanoma,Small Cell Lung Carcinoma,Bladder Cancer,Undifferentiated Pleomorphic Sarcoma,Histiocytoma, Malignant Fibrous,Pancreatic Cancer,Squamous Cell Carcinoma Of Head And Neck,Non-small Cell Lung Cancer,Head And Neck Cancer,Endometrial Carcinoma

PROVIDER: 2290382 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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