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MGD019 DART Protein in Unresectable/Metastatic Cancer

ABSTRACT: The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics (PK) pharmacodynamics and preliminary antitumor activity of lorigerlimab. This Phase 1, open-label study will characterize safety, dose-limiting toxicities (DLTs), and maximum tolerated/administered dose (MTD/MAD) of MGD019. Dose escalation will occur in a 3+3+3 design in patients with advanced solid tumors of any histology. Once the MTD/MAD is determined, a Cohort Expansion Phase will be enrolled to further characterize safety and initial anti-tumor activity in patients with specific tumor types anticipated to be sensitive to dual checkpoint blockade.

DISEASE(S): Cutaneous Melanoma,Melanoma,Colorectal Cancer,Advanced Cancer,Squamous Cell Non Small Cell Lung Cancer,Prostate Cancer Metastatic,Solid Tumor, Adult

PROVIDER: 2291043 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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