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TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

ABSTRACT: This is a phase 1/1b open label, multicenter dose escalation and dose expansion study to investigate the safety, tolerability and anti-tumor activity of TPST-1120, a small molecule selective antagonist of PPARα (peroxisome proliferator activated receptor alpha) as monotherapy and in combination with a systemic anticancer agent, nivolumab, an anti-PD1 antibody, in subjects with advanced solid tumors.

DISEASE(S): Carcinoma,Sarcoma,Metastatic Castration Resistant Prostate Cancer,Triple Negative Breast Neoplasms,Colorectal Cancer,Urothelial Carcinoma,Triple-negative Breast Cancer,Pancreatic Cancer,Squamous Cell Carcinoma Of Head And Neck,Non-small Cell Lung Cancer,Carcinoma, Renal Cell,Gastroesophageal Cancer,Renal Cell Carcinoma,Cholangiocarcinoma,Hepatocellular Carcinoma

PROVIDER: 2296301 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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2023-03-11 | PXD036558 | Pride

The immunocytokine PD1-IL2v overcomes resistance to tumor immunity, and synergizes with anti-PD-L1

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