Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A T Drain Approach Treating Anastomotic Leaks After Gastrointestinal Surgery

ABSTRACT: Assessing the use of a T drain approach for an anastomotic leak after gastrointestinal surgery. The study’s aim is to retrospectively assess the safety and benefits of this approach.

DISEASE(S): Diverticulitis,Colorectal Cancer,Anastomotic Leak

PROVIDER: 2307451 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Drain Fluid Amylase as an early biomarker of anastomotic leak in low colorectal anastomoses

Project description:Interventions: Measure amylase levels in drain fluid daily after low colorectal anastomoses as an early indicator of anastomotic leak. - a small sample of drain fluid will be collected daily while pelvic drain is in situ during hospital admission following colorectal surgery and samples will be sent to the local pathology service for measurement of amylase - the amylase levels in drain fluid at each collection while the drain is in-situ will be collected and correlated to the clinical course - clinical course following surgery will be observed during admission (and data collected after patient has been discharged, retrospective data collection). - Follow up consultation at 6 weeks following surgery Primary outcome(s): Daily amylase levels in the drain fluid post-operatively. The measurement of amylase in drain fluid is measured and reported by local pathology service.[Day 1, Day 2, Day 3, Day 4 and Day 5, post operatively, or until pelvic drain is removed. ] Study Design: Purpose: Screening;Duration: Longitudinal;Selection: Defined population;Timing: Both

| 2471651 | ecrin-mdr-crc

Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation and neointimal hyperplasia

Project description:Background: Clinical failure of arteriovenous fistulae (AVF) is frequently due to juxta-anastomotic neointimal hyperplasia (JANIH). Although the mouse AVF model recapitulates human AVF maturation, previous studies focused on the outflow vein distal to the anastomosis. We hypothesized that the juxta-anastomotic area (JAA) has increased NIH compared to the outflow vein. Method: AVF were created in C57BL/6 mice without or with chronic kidney disease (CKD). Temporal and spatial changes of the JAA were examined using histology and immunofluorescence. Computational techniques were used to model the AVF. RNA-seq and bioinformatic analyses were performed to compare the JAA with the outflow vein. The jugular vein to carotid artery AVF model was created in Wistar rats. Result: The neointima in the JAA shows increased volume compared to the outflow vein. Computational modeling shows increased volume of disturbed flow at the JAA compared to the outflow vein. Endothelial cells are immediately lost from the wall contralateral to the fistula exit, followed by thrombus formation and JANIH. Gene Ontology (GO) enrichment analysis of the 1862 differentially expressed genes (DEG) between the JANIH and the outflow vein identified 525 overexpressed genes. The rat jugular vein to carotid artery AVF showed changes similar to the mouse AVF. Conclusion: Disturbed flow through the JAA correlates with rapid endothelial cell loss, thrombus formation, and JANIH; late endothelialization of the JAA channel correlates with late AVF patency. Early thrombus formation in the JAA may influence later development of JANIH.

2023-12-08 | GSE249267 | GEO

Project description:Esophageal microbiome correlates with post esophagectomy anastomotic leak in cancer patients

| PRJNA979957 | ENA

citizen science approach for ctenophore identification

Project description:Assessing the value of a citizen science approach for ctenophore identification

| PRJEB48037 | ENA

A Phase 2 study of efficacy: The validation of Gastrografin measurement in postsurgical samples following low anterior resection when the rectal tube is flushed with Gastrografin

Project description:Interventions: Patients who undergo low anterior resection without a diverting loop ileostomy and have a rectal tube and pelvic drain will be invited to participate. Only participants who are included in the study (by providing written consent) will receive Gastrografin flushes of rectal tube four times per day (QID), to replace saline flushes QID. At Day 1, Day 2, Day 3, Day 4, Day 5 (or until rectal tubes is in situ) after surgery: Participants will receive rectal tube flushing with 30 ml Gastrografin (25% v/v in saline) 4 times per day (QID). At 06:30am and 16:30pm, a 20 ml sample of drain fluid will be collected and stored until all samples during hospital admission are collected (for measurement of Gastrografin by DECT and ICPMS). Also, a sample from the rectal tube will be collected on Day 1 after surgery to confirm the presence of luminal Gastrografin. Patients will be observed during the hopital admission following surgery. The presence of Gastrografin will be measured in each sample by DECT and ICPMS. The clinical course post surgery will be monitored in all participants and the group will be catagorised into patients that DO NOT experience an anastomotic leak following surgery and patients that DO experience an anastomotic leak following surgery. Primary outcome(s): Level of Gastrografin in drain fluid will be measured by DECT and ICP-MS[Day 1, 2, 3, 4, 5 or until rectal tube is in situ];Anastomotic leak after surgery by clinical assessment and CT (as per standard care)[Day 1, 2, 3, 4, 5 post surgery] Study Design: Purpose: Diagnosis; Allocation: Non-randomised trial

| 2470927 | ecrin-mdr-crc

FishEUTrust: Seafood traceability using targeted metagenomic approach

Project description:FishEUTrust: Seafood traceability assessing trough microbial communities: proposing a targeted metagenomic approach

| PRJEB78552 | ENA

APPROACH Microbiome

Project description:APPROACH Microbiome

| PRJEB48705 | ENA

APPROACH Microbiome

Project description:APPROACH Microbiome

| PRJEB48706 | ENA

REINFORCEMENT ANASTOMOSIS WITH Modified Cyanacrylate IN Patients Undergoing to Oncologic Colorectal Surgery With Colorectal Anastomosis

Project description:In colorectal surgery about 30% of postoperative mortality is attributed to anastomotic leak, whit an incidence range between 1.8% and 15.9%. Preventing the anastomotic leak can therefore bring benefits to the patient and the health system. To date we have technologically advanced suturizers and the correct realization (well-vascularized margins, not in tension, etc.) remains crucial to prevent anastomotic dehiscence. Experimental results demonstrate that modified cyanacrylate is a suitable potential "reinforcement" on intestinal anastomoses (manual or linear intra-corporeal). Applied after mechanical anastomosis, it polymerizes in a short time, closing the spaces of the suture line between one point and the other, expressing an adhesive, hemostatic and sealing action on the tissues, also creating an effective antiseptic barrier towards of the most common infectious or pathogenic agents.

| 2261859 | ecrin-mdr-crc

Incidence and risk factors for anastomotic bleeding in lower gastrointestinal surgery.

Project description:OBJECTIVE:Although major anastomotic bleeding after lower gastrointestinal surgery is considered rare, it can be life-threatening if not properly managed. The objective of this study was to assess the incidence of postoperative lower gastrointestinal intraluminal bleeding and to identify its potential risk factors. This retrospective cohort study used data from charts of 314 patients who underwent digestive surgery of the colon or small intestine. Details are reported for their sociodemographic data, surgical approach, comorbidities, timing and presentation of intraluminal bleeding events, bleeding diagnosis, treatment strategies, hospital length of stay, and clinical complications. RESULTS:A total of 7 patients (2.3%) experienced intraluminal bleeding in the postoperative period. The average length of hospital stay before discharge was 12 days (median?=?13 days). Patients with intraluminal bleeding had a significantly higher percentage of coronary artery diseases compared to patients without intraluminal bleeding (P value?=?.04), as well as having a cancer diagnosis (P value?=?.02). The clinical complications that were more likely in patients with intraluminal bleeding included requiring blood transfusions (P value?=?.01), reduction in hemoglobin (P value?=?.001), cardiac ischemia (P value?=?.02), and atrial fibrillations (P value?=?.02).

| S-EPMC6607592 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data