Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer

ABSTRACT: This phase II trial studies how well retreatment with panitumumab works compared to standard of care regorafenib or trifluridine and tipiracil hydrochloride (TAS-102) in treating patients with colorectal cancer that is negative for RAS wild-type colorectal cancer has spread to other places in the body (metastatic), and/or cannot be removed by surgery (unresectable), and is negative for resistance mutations in blood. Treatment with panitumumab may interfere with the ability of tumor cells to grow and spread. Some tumors need growth factors to keep growing. Growth factor antagonists, such as regorafenib, may interfere with the growth factor and stop the tumor from growing. Drugs used in chemotherapy, such as TAS-102, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving panitumumab may work better in treating patients with colorectal cancer than with the usual treatment of regorafenib or TAS-102.

DISEASE(S): Adenocarcinoma,Stage Iva Colorectal Cancer Ajcc V8,Stage Ivb Rectal Cancer Ajcc V8,Stage Iiib Colon Cancer Ajcc V8,Carcinoma,Metastatic Colorectal Carcinoma,Stage Iv Rectal Cancer Ajcc V8,Stage Iiic Rectal Cancer Ajcc V8,Stage Iii Colon Cancer Ajcc V8,Stage Iiic Colorectal Cancer Ajcc V8,Metastatic Colon Adenocarcinoma,Stage Ivc Rectal Cancer Ajcc V8,Stage Ivb Colorectal Cancer Ajcc V8,Stage Iv Colon Cancer Ajcc V8,Stage Iiib Rectal Cancer Ajcc V8,Stage Iiia Colon Cancer Ajcc V8,Unresectable Colon Adenocarcinoma,Colorectal Neoplasms,Stage Iva Colon Cancer Ajcc V8,Stage Ivc Colon Cancer Ajcc V8,Stage Iiic Colon Cancer Ajcc V8,Stage Iiib Colorectal Cancer Ajcc V8,Stage Ivc Colorectal Cancer Ajcc V8,Unresectable Colorectal Carcinoma,Stage Iv Colorectal Cancer Ajcc V8,Metastatic Rectal Adenocarcinoma,Stage Iiia Colorectal Cancer Ajcc V8,Stage Iiia Rectal Cancer Ajcc V8,Stage Ivb Colon Cancer Ajcc V8,Unresectable Rectal Adenocarcinoma,Stage Iva Rectal Cancer Ajcc V8,Rectal Neoplasms,Stage Iii Rectal Cancer Ajcc V8,Stage Iii Colorectal Cancer Ajcc V8,Colonic Neoplasms

PROVIDER: 2308817 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR