Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies
Ontology highlight
ABSTRACT:
DISEASE(S): Squamous Cell Carcinoma Of Head And Neck,Carcinoma,Esophageal Scc,Colorectal Cancer,Carcinoma, Non-small-cell Lung,Head And Neck Squamous Cell Carcinoma,Nsclc,hnscc,esophagus Scc,gist,crc,Non-small Cell Lung Carcinoma,Esophageal Squamous Cell Carcinoma,Gastrointestinal Stromal Tumors
PROVIDER: 2309436 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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Project description:The study comprises of 24 subjects that have been exposed to low (H) and high dose (O) ambient traffic pollution. Each subject has been exposed to 2 different exposure site. Blood samples were taken at both sites of which circulating miRNAs in plasma have been prepared
2018-02-06 | GSE106221 | GEO
Project description:<p>This pharmacogenomic study focused on the response of patients with MDD to an 8-week course of treatment with citalopram or escitalopram.</p> <p>Briefly, clinical assessments and research assessments were performed at each study visit as summarized in Table 1. 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| phs000670 | dbGaP
Project description:Primary objectives: Phase I
The main objective of the phase I part is to determine safety and the recommended phase II dose (RP2D) of the triple combination.
Phase II
The main objective of the phase II part is to determine efficacy of the triplet combination defined by objective response rate according to RECIST 1.1.
Primary endpoints: For the phase I dose-escalation trial:
The primary endpoint is the incidence of DLTs leading to a RP2D. The RP2D of the triplet will be the MTD which is defined as the dose level that can be given to 6 subjects such that not more than 1 subject experiences a DLT.
For the phase II trial:
The primary endpoint is best overall response (OR), defined as complete response (CR) + partial response (PR) within 6 months, based on RECIST 1.1.
| 2539846 | ecrin-mdr-crc
Project description:Purpose: The goal of this study was the transcriptome high-throughput data analysis of TR3-56 cells isolated from peripheral blood of healthy and T1D subjects Methods: total RNA profile of human TR3-56 cells from healthy and T1D subjects (1. Healthy Subject, 2.Healthy Subject, 3.Healthy Subject; 4. T1D subject, 5. T1D subject, 6. T1D subject; deeep sequencing, using Ovation SoLo RNA-seq Library Preparation KIt (NuGen), Library were prepared for sequencing on NextSeq 500 (llumina technology) Results: Principal component analysis and unsupervised clustering showed that TR3-56 cells from healthy donors are transcriptionally different from TR3-56 cells isolated from T1D subjects. Conclusions: Several genes are differently regulated between TR3-56 cells from T1D and healthy donors.
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| phs000594 | dbGaP
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2017-10-31 | GSE78963 | GEO
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2023-03-20 | E-MTAB-12829 | biostudies-arrayexpress
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