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Anti-PD-1 +/- RT for MSI-H Solid Tumors

ABSTRACT: To determine if the out-of-field ORR is improved with the addition of radiation therapy to anti-PD-1 for patients with MSI-H/dMMR metastatic solid tumors. Determine the rates of in-field tumor control, disease control (stable disease, partial response, complete response), durability of disease response, progression-free survival, overall survival, and to assess quality of life and toxicity. Determine the chronology and profile of the radiation-associated immune response.

DISEASE(S): Microsatellite Instability,Microsatellite Instability High,Solid Tumor,Colorectal Cancer,Colorectal Neoplasms,Mismatch Repair Deficiency

PROVIDER: 2309480 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Dickkopf 1 Impairs Sensitivity to PD-1 Blockade through CD8+ T Cell Inactivation in dMMR/MSI Colorectal Cancer

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2021-04-07 | GSE149206 | GEO

PD-1 Antibody Combined With COX Inhibitor in MSI-H/dMMR or High TMB Colorectal Cancer

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2022-05-30 | GSE205026 | GEO

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