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Haplo / Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted γδ T Cells for Relapsed or Refractory Solid Tumour


ABSTRACT: This clinical trial is an open-label, single-centre, dose escalation, phase I study designed to investigate the safety and tolerability of Haploidentical / Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted Gamma Delta (γδ) T Cells (CTM-N2D) in Subjects with Relapsed or Refractory Solid Tumour. The study objectives of this phase I study are to determine the safety, activity and the safe dose of haploidentical or allogeneic NKG2DL-targeting chimeric antigen receptor-grafted γδ T cells given four times weekly in patients with relapsed or refractory solid tumors of different types.

DISEASE(S): Nasopharyngeal Carcinoma,Sarcoma,Triple Negative Breast Neoplasms,Colorectal Cancer,Gastric Cancer,Prostate Cancer,Triple Negative Breast Cancer

PROVIDER: 2317628 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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