Dataset Information

Assessing diet, exercise, sleep and other lifestyle habits in people with a known increased risk for bowel cancer and who have regular colonoscopies

ABSTRACT: Interventions: We propose to conduct a prospective observational study to investigate how change in diet and lifestyle patterns over time impacts the development of precancerous colorectal lesions or colorectal cancer in individuals at above average risk of colorectal cancer and undergoing a colonoscopy surveillance - the ‘Southern Cooperative Program for the prevention of colorectal cancer’ (SCOOP). Data regarding patients’ colonoscopies will be extracted from the SCOOP database. Participants enrolled in the SCOOP program will be invited to complete the diet and lifestyle survey over the period of three years (in years 1 (baseline survey), 2 and 3 (follow-up surveys)). The survey can be completed by the participants either online, by clicking on a provided link or scanning a QR code. It is expected that each survey will require around 40-50 minutes to be filled out. The exposure variables include: -Dietary intake (using a validated food frequency questionnaire from the Australian Eating Survey), -Physical activity (using the International Physical Activity Questionnaire (IPAQ-L)), -Sleep patterns (Pittsburgh Sleep Quality Index (PSQI), Obstructive sleep apnoea screening questionnaire (OSAS), and Insomnia Severity Index questionnaire, -Smoking status, -Body mass index (BMI), -Aspirin intake, and -Comorbidities including diabetes. Primary outcome(s): The primary outcome of this study will be the dietary pattern that will be assessed using a validated food frequency questionnaire. [This will be assessed at baseline (year 1), years 2 and 3 at anytime during the three year observation period. Individuals whose colonoscopies are due within one year will receive only one diet survey (baseline), while those whose colonoscopies are due in two years’ time will receive only two diet surveys before their next scheduled colonoscopy. Most patients under surveillance will receive regular colonoscopies at intervals of 3 or 5 years, and they will be able to take part in all three diet surveys until the next scheduled colonoscopy.];Another primary outcome of this study will be sleep quality assessed by a validated International Physical Activity Questionnaire (IPAQ-L). [This will be assessed at baseline (year 1), years 2 and 3 at anytime during the three year observation period. Individuals whose colonoscopies are due within one year will receive only one physical activity survey (baseline), while those whose colonoscopies are due in two years’ time will receive only two physical activity surveys before their next scheduled colonoscopy. Most patients under surveillance will receive regular colonoscopies at intervals of 3 or 5 years, and they will be able to take part in all three physical activity surveys until the next scheduled colonoscopy.];Another primary outcome of this study will be sleep quality assessed by a validated Pittsburgh Sleep Quality Index (PSQI). [This will be assessed at baseline (year 1), years 2 and 3 at anytime during the three year observation period. Individuals whose colonoscopies are due within one year will receive only one sleep survey (baseline), while those whose colonoscopies are due in two years’ time will receive only two sleep surveys before their next scheduled colonoscopy. Most patients under surveillance will receive regular colonoscopies at intervals of 3 or 5 years, and they will be able to take part in all three sleep surveys until the next scheduled colonoscopy.] Study Design: Purpose: Screening;Duration: Longitudinal;Selection: Defined population;Timing: Prospective

DISEASE(S): Public Health-epidemiology,Diet And Nutrition-other Diet And Nutrition Disorders,Colorectal Cancer,Cancer-bowel-back Passage (rectum) Or Large Bowel (colon)

PROVIDER: 23385 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Similar Datasets

Project description:Short sleep duration is associated with adverse metabolic, cardiovascular, and inflammatory effects. Co-twin study methodologies account for familial (e.g., genetics and shared environmental) confounding, allowing assessment of subtle environmental effects, such as the effect of short habitual sleep duration on gene expression. Therefore, we sought to investigate gene expression in monozygotic twins discordant for actigraphically phenotyped habitual sleep duration. Eleven healthy monozygotic twin pairs (82% female; mean age 42.7 years; SD=18.1), selected based on subjective sleep duration discordance, were objectively phenotyped for habitual sleep duration with two-weeks of wrist actigraphy. Peripheral blood leukocyte (PBL) RNA from fasting blood samples was obtained on the final day of actigraphic measurement and hybridized to Illumina humanHT-12 microarrays. Differential gene expression was determined between paired samples and mapped to functional categories using Gene Ontology. Next, a more comprehensive gene set enrichment analysis was performed based on the entire PBL transcriptome. The mean 24 hour sleep duration of the total sample was 439.2 minutes (SD=46.8 minutes; range 325.4 to 521.6 minutes). Mean within-pair sleep duration difference per 24 hours was 64.4 minutes (SD=21.2; range 45.9 to 114.6 minutes). The twin cohort displayed distinctive pathway enrichment based on sleep duration differences. Short sleep was associated with up-regulation of genes involved in transcription, ribosome, translation and oxidative phosphorylation. Unexpectedly, genes down-regulated in short sleep twins were highly enriched in immuno-inflammatory pathways such interleukin signaling and leukocyte activation, as well as developmental programs, coagulation cascade, and cell adhesion. Objectively assessed habitual sleep duration in monozygotic twin pairs appears to be associated with distinct patterns of differential gene expression and pathway enrichment. By accounting for familial confounding and measuring real life sleep duration, our study shows the transcriptomic effects of short sleep on dysregulated immune response and provides a potential link between sleep deprivation and adverse metabolic, cardiovascular and inflammatory outcomes.

Project description:The Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) is a resource developed to facilitate research on genetic and environmental factors on common diseases and healthy aging. The RPGEH resource links biospecimens, health surveys, and comprehensive electronic medical records on broadly consented adult members of Kaiser Permanente Medical Care Plan, Northern California Region (KPNC). KPNC is an integrated health care delivery system with a membership of approximately 3.3 million people in northern California. The membership of KPNC is representative of the general population in the 14 county area in which facilities are located, although extremes of income are underrepresented. At the end of 2013, the RPGEH resource included: (1) demographic and behavioral surveys from over 430,000 participants; (2) biospecimens (DNA, serum, plasma, and/or saliva) from over 204,000 participants, including over 13,000 pregnant women; (3) genome-wide genotype data (70 billion SNP genotypes) on over 100,000 participants, including the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort; and (4) the longitudinal electronic medical records of the participants. The RPGEH was developed beginning in 2005 at the Division of Research of Kaiser Permanente Northern California by Catherine Schaefer (Director), Neil Risch (Co-Director), Lisa Croen, Eric Jorgenson, Lawrence Kushi, Charles Quesenberry, Sarah Rowell, Carol Somkin, Stephen Van den Eeden, Larry Walter, and Rachel Whitmer. Funding of the RPGEH was provided to C. Schaefer (PI) and N. Risch (co-PI) by the Wayne and Gladys Valley Foundation, The Ellison Medical Foundation, the Robert Wood Johnson Foundation, Kaiser Permanente Northern California, and the Kaiser Permanente National and Regional Community Benefit Programs. The GERA cohort was funded by a grant from NIH to RPGEH and UCSF (RC2 AG036607; C. Schaefer and N. Risch, PIs). At the time of the award of the RC2 project in late 2009, the RPGEH had established a cohort of about 140,000 individuals who had answered a detailed survey, provided saliva samples for extraction of DNA, and given broad consent for the use of their data in studies of health and disease. Survey and Cohort Recruitment. Initially, the RPGEH developed electronic disease registries to enable identification of phenotypes, using algorithms applied to EMR data. In 2007, the RPGEH mailed a four page survey to 1.9 million adult (≥ 18 years old) members of KPNC who had been members for two years or more, to obtain data on demographic and behavioral factors complementary to the clinical data in the EMR. The survey materials included a cover letter introducing the RPGEH, a two page list of Frequently Asked Questions, and the survey, which included questions on demographic factors such as education, race-ethnicity, income and marital status, dietary factors, physical activity, smoking, and alcohol consumption, as well as reproductive history and reproductive health. Members whose electronic medical records indicated a preference for written communications in Chinese or Spanish received survey materials both in English and a Chinese or Spanish translation. Approximately 400,000 completed surveys were returned. Saliva Sample Collection. Beginning in July 2008, respondents to the survey were asked to sign and return a consent form and authorization for use and disclosure of protected health information. The consent form authorized broad use of biospecimens, survey data, and data from participants' electronic health records for use in studies of genetic and environmental influences on health and disease. Respondents who returned completed consent forms were mailed (Oragene) saliva collection kits; more than 132,000 saliva samples were collected in two years. Completed saliva kits were scanned and archived in a temporary biorepository at the KPNC Division of Research. In late 2009, the RPGEH began collection of saliva samples from the California Men's Health Study (CMHS), a cohort that had been previously assembled in 2002-2003 and had been excluded from the RPGEH survey mailing with the intent of later adding CMHS participants to the assembled RPGEH cohort. The CMHS was developed to facilitate research on prostate cancer and other conditions in older men; the study protocol is described in <a href="http://www.ncbi.nlm.nih.gov/pubmed/16813653" target="_blank">Enger, et al., 2006</a>. It enrolled and surveyed more than 40,000 men in KPNC, ages 45-69 years, who were members of KPNC during 2002-2003. CMHS men completed two mailed surveys with demographic and behavioral data similar to that of the RPGEH. The data on analogous variables were reconciled and integrated with the data derived from the RPGEH cohort for use in the RPGEH resource. By 2011, RPGEH collected approximately 15,400 saliva samples from men participating in the CMHS. RPGEH Access and Collaborations Website and Procedures. The RPGEH maintains a web portal for inquiries and applications for collaboration and access to data. The url is: <a href="https://rpgehportal.kaiser.org/" target="_blank">https://rpgehportal.kaiser.org/</a>. RPGEH has an application process and an Access Review Committee that reviews applications for collaboration and use. For more information, please contact RPGEH through the website.

Dataset Information

Assessing diet, exercise, sleep and other lifestyle habits in people with a known increased risk for bowel cancer and who have regular colonoscopies

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets