BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

ABSTRACT: BOLD-100 is an intravenously administered sterile solution containing the ruthenium-based small molecule. BOLD-100 has been shown to preferentially decrease the expression of GRP78 in tumour cells and ER stressed cells when compared to normal cells. BOLD-100 will be combined with cytotoxic FOLFOX chemotherapy in this study, with a dose escalation cohort to ensure tolerability and safety, followed by a cohort expansion phase.

DISEASE(S): Metastatic Colorectal Cancer,Pancreatic Cancer Metastatic,Gastric Cancers,Gastric Carcinoma,Colorectal Cancerpancreatic Cancergastric Cancerscholangiocarcinoma,Colorectal Cancer,Pancreatic Cancer,Cholangiocarcinoma Metastatic,Cholangiocarcinoma

PROVIDER: 2341799 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR