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SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 Trial

ABSTRACT: This phase Ib/II trial studies the side effects and best dose of SX-682 that can be given alone and in combination with nivolumab in treating patients with RAS-Mutated, microsatellite stable (MSS) colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). SX-682 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving SX-682 alone and together with nivolumab may kill more tumor cells.

DISEASE(S): Adenocarcinoma,Stage Ivb Rectal Cancer Ajcc V8,Stage Iiib Colon Cancer Ajcc V8,Metastatic Colorectal Carcinoma,Stage Iv Rectal Cancer Ajcc V8,Stage Iiic Rectal Cancer Ajcc V8,Stage Iii Colon Cancer Ajcc V8,Metastatic Colon Adenocarcinoma,Stage Ivc Rectal Cancer Ajcc V8,Stage Iv Colon Cancer Ajcc V8,Stage Iiib Rectal Cancer Ajcc V8,Stage Iiia Colon Cancer Ajcc V8,Unresectable Colon Adenocarcinoma,Colorectal Neoplasms,Stage Iva Colon Cancer Ajcc V8,Stage Ivc Colon Cancer Ajcc V8,Stage Iiic Colon Cancer Ajcc V8,Metastatic Rectal Adenocarcinoma,Stage Iiia Rectal Cancer Ajcc V8,Stage Ivb Colon Cancer Ajcc V8,Unresectable Rectal Adenocarcinoma,Stage Iva Rectal Cancer Ajcc V8,Rectal Neoplasms,Stage Iii Rectal Cancer Ajcc V8,Colonic Neoplasms

PROVIDER: 2355422 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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