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Surufatinib, Toripalimab and Chemotherapy in Second-line MT and MSS CRC

ABSTRACT: To determine the efficacy and safety of surufatinib, toripalimab and chemotherapy in second-line RAS/BRAF mutant and MSS colorectal cancer

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2359596 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Surufatinib increases cholangiocarcinoma cells radiosensitivity by anti-tumor proliferation and inhibition of macrophage M2 polarization

Project description:This study confirmed the radiosensitizing effects of surufatinib on cholangiocarcinoma. The mechanism is that surufatinib can activate TLR3, up-regulate the expression of TRIF protein, increase DNA damage and apoptosis after radiation, and up-regulate NF- κB signal pathway to inhibit M2 polarization of tumor-associated macrophages, thus enhance radiosensitivity.

2024-06-30 | GSE269494 | GEO

Surufatinib Combined With Sintilimab for Advanced MSS-Type Colorectal Cancer : a Phase II Study

Project description:A phase II study to assess the efficacy and safety of Surufatinib combined with Sintilimab as a second-line treatment in patients with advanced MSS-Type CRC.

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Surufatinib plus toripalimab in patients with advanced solid tumors: a single-arm, open-label, phase 1 trial.

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Second-line Surufatinib Combined With Chemotherapy in Advanced CRC

Project description:A phase II, muti-cohort study to assess the efficacy and safety of Surufatinib combined with chemotherapy as a second-line treatment in patients with advanced CRC

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Expression profiles of a panel of MSS and MSI colon cancer cell lines

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Regorafenib Alone or in Combination With High/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer

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Expression profiles of a panel of MSS and MSI colon cancer cell lines

2012-02-07 | GSE35566 | GEO