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Study on the Correlation Between Gene Mutation and TCM Syndrome Types in Metastatic Colorectal Cancer

ABSTRACT: To explore the correlation between gene mutations of metastatic colorectal cancer and TCM syndrome types based on Second-generation sequencing technology.

DISEASE(S): Colorectal Neoplasms,Gene Mutation-related Cancer,Traditional Chinese Medicine

PROVIDER: 2360178 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Study on the correlation between gene mutation and TCM syndrome types in metastatic colorectal cancer

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Project description:Guided by the idea of combining disease differentiation with syndrome differentiation in traditional Chinese medicine, this study used the form of questionnaire to summarize the changes of TCM syndromes, TCM constitution types in colorectal cancer patients before and after surgery. The Next-generation sequencing technology was used to explore the changes and differences of intestinal microorganisms before and after surgery. The correlation between changes of TCM syndromes, TCM constitution types, intestinal microbial evolution and tumor biological characteristics in colorectal cancer patients before and after surgery was analyzed. To explore the rationality of TCM in the prevention and treatment of colorectal cancer recurrence and metastasis in order to guide the individualized treatment and dietary regulation of TCM.

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Human CD8 T central memory (Tcm) cells: Control vs. norepinephrine (NE) treated

Project description:Transcriptional profiling of CD8 Tcm cells comparing untreated control cells to 16 hour norepinephrine treated cells. The goal was to examine the impact of norepinephrine treatment on CD8 Tcm cell global gene expression compared to untreated cells, and also to examine changes that occurred in resting cells and activated cells 24 and 72 hours after stimulation with CD3/28 beads. Two-conditional experiment: Control vs. NE treated CD8 Tcm cells. Biological replicates: 3 replicates for 0 hour and 24 hours, and 2 replicates for 72 hours. Each sample consisted of pooled RNA from 3 different donors.

2015-03-01 | E-GEOD-64635 | biostudies-arrayexpress

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2005-01-01 | E-TABM-40 | biostudies-arrayexpress

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